| Title |
A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay
|
|---|---|
| Published in |
Nature Communications, June 2017
|
| DOI | 10.1038/ncomms15943 |
| Pubmed ID | |
| Authors |
Zhiyuan Hu, Christopher Yau, Ahmed Ashour Ahmed |
| Abstract |
Nonsense-mediated decay (NMD) eliminates transcripts with premature termination codons. Although NMD-induced loss-of-function has been shown to contribute to the genesis of particular cancers, its global functional consequence in tumours has not been characterized. Here we develop an algorithm to predict NMD and apply it on somatic mutations reported in The Cancer Genome Atlas. We identify more than 73 K mutations that are predicted to elicit NMD (NMD-elicit). NMD-elicit mutations in tumour suppressor genes (TSGs) are associated with significant reduction in gene expression. We discover cancer-specific NMD-elicit signatures in TSGs and cancer-associated genes. Our analysis reveals a previously unrecognized dependence of hypermutated tumours on hypofunction of genes that are involved in chromatin remodelling and translation. Half of hypermutated stomach adenocarcinomas are associated with NMD-elicit mutations of the translation initiators LARP4B and EIF5B. Our results unravel strong therapeutic opportunities by targeting tumour dependencies on NMD-elicit mutations. |
X Demographics
The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 24% |
| Australia | 2 | 8% |
| France | 1 | 4% |
| China | 1 | 4% |
| United Kingdom | 1 | 4% |
| Russia | 1 | 4% |
| Unknown | 13 | 52% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 13 | 52% |
| Members of the public | 10 | 40% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | <1% |
| Unknown | 117 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 22% |
| Student > Ph. D. Student | 25 | 21% |
| Student > Master | 11 | 9% |
| Student > Bachelor | 10 | 8% |
| Student > Doctoral Student | 5 | 4% |
| Other | 12 | 10% |
| Unknown | 29 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 43 | 36% |
| Agricultural and Biological Sciences | 21 | 18% |
| Medicine and Dentistry | 7 | 6% |
| Engineering | 5 | 4% |
| Immunology and Microbiology | 5 | 4% |
| Other | 7 | 6% |
| Unknown | 30 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2023.
All research outputs
#3,181,205
of 25,775,807 outputs
Outputs from Nature Communications
#33,114
of 58,407 outputs
Outputs of similar age
#55,393
of 329,401 outputs
Outputs of similar age from Nature Communications
#667
of 1,066 outputs
Altmetric has tracked 25,775,807 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 58,407 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.4. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
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We're also able to compare this research output to 1,066 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.