| Title |
Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models
|
|---|---|
| Published in |
Nature Communications, April 2017
|
| DOI | 10.1038/ncomms15028 |
| Pubmed ID | |
| Authors |
In Young Hwang, Elvin Koh, Adison Wong, John C. March, William E. Bentley, Yung Seng Lee, Matthew Wook Chang |
| Abstract |
Bacteria can be genetically engineered to kill specific pathogens or inhibit their virulence. We previously developed a synthetic genetic system that allows a laboratory strain of Escherichia coli to sense and kill Pseudomonas aeruginosa in vitro. Here, we generate a modified version of the system, including a gene encoding an anti-biofilm enzyme, and use the probiotic strain Escherichia coli Nissle 1917 as host. The engineered probiotic shows in vivo prophylactic and therapeutic activity against P. aeruginosa during gut infection in two animal models (Caenorhabditis elegans and mice). These findings support the further development of engineered microorganisms with potential prophylactic and therapeutic activities against gut infections. |
X Demographics
The data shown below were collected from the profiles of 103 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 20 | 19% |
| United Kingdom | 12 | 12% |
| India | 4 | 4% |
| France | 3 | 3% |
| Denmark | 3 | 3% |
| Spain | 3 | 3% |
| Switzerland | 2 | 2% |
| Australia | 2 | 2% |
| Ireland | 2 | 2% |
| Other | 14 | 14% |
| Unknown | 38 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 53 | 51% |
| Scientists | 44 | 43% |
| Practitioners (doctors, other healthcare professionals) | 3 | 3% |
| Science communicators (journalists, bloggers, editors) | 3 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 602 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | <1% |
| Australia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Belgium | 1 | <1% |
| Denmark | 1 | <1% |
| China | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 595 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 110 | 18% |
| Student > Master | 82 | 14% |
| Student > Bachelor | 81 | 13% |
| Researcher | 73 | 12% |
| Student > Doctoral Student | 32 | 5% |
| Other | 72 | 12% |
| Unknown | 152 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 162 | 27% |
| Agricultural and Biological Sciences | 99 | 16% |
| Immunology and Microbiology | 42 | 7% |
| Engineering | 33 | 5% |
| Chemical Engineering | 25 | 4% |
| Other | 70 | 12% |
| Unknown | 171 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 102. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2023.
All research outputs
#420,942
of 25,713,737 outputs
Outputs from Nature Communications
#6,907
of 58,180 outputs
Outputs of similar age
#8,809
of 325,510 outputs
Outputs of similar age from Nature Communications
#177
of 902 outputs
Altmetric has tracked 25,713,737 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 58,180 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.4. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,510 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 902 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.