| Title |
Common variants of FUT2 are associated with plasma vitamin B12 levels
|
|---|---|
| Published in |
Nature Genetics, September 2008
|
| DOI | 10.1038/ng.210 |
| Pubmed ID | |
| Authors |
Aditi Hazra, Peter Kraft, Jacob Selhub, Edward L Giovannucci, Gilles Thomas, Robert N Hoover, Stephen J Chanock, David J Hunter |
| Abstract |
We identified a strong association (P = 5.36 x 10(-17)) between rs492602 in FUT2 and plasma vitamin B(12) levels in a genome-wide scan (n = 1,658) and an independent replication sample (n = 1,059) from the Nurses' Health Study. Women homozygous for the rs492602[G] allele had higher B(12) levels. This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B(12) absorption and plasma levels. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 166 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| United States | 2 | 1% |
| Netherlands | 1 | <1% |
| Slovakia | 1 | <1% |
| Unknown | 160 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 43 | 26% |
| Student > Ph. D. Student | 25 | 15% |
| Student > Master | 20 | 12% |
| Student > Bachelor | 20 | 12% |
| Other | 12 | 7% |
| Other | 27 | 16% |
| Unknown | 19 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 52 | 31% |
| Biochemistry, Genetics and Molecular Biology | 34 | 20% |
| Medicine and Dentistry | 26 | 16% |
| Nursing and Health Professions | 9 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Other | 15 | 9% |
| Unknown | 25 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2022.
All research outputs
#5,637,831
of 23,577,761 outputs
Outputs from Nature Genetics
#4,957
of 7,294 outputs
Outputs of similar age
#25,186
of 88,005 outputs
Outputs of similar age from Nature Genetics
#39
of 59 outputs
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