| Title |
Early dissemination seeds metastasis in breast cancer
|
|---|---|
| Published in |
Nature, December 2016
|
| DOI | 10.1038/nature20785 |
| Pubmed ID | |
| Authors |
Hedayatollah Hosseini, Milan M. S. Obradović, Martin Hoffmann, Kathryn L. Harper, Maria Soledad Sosa, Melanie Werner-Klein, Lahiri Kanth Nanduri, Christian Werno, Carolin Ehrl, Matthias Maneck, Nina Patwary, Gundula Haunschild, Miodrag Gužvić, Christian Reimelt, Michael Grauvogl, Norbert Eichner, Florian Weber, Andreas D. Hartkopf, Florin-Andrei Taran, Sara Y. Brucker, Tanja Fehm, Brigitte Rack, Stefan Buchholz, Rainer Spang, Gunter Meister, Julio A. Aguirre-Ghiso, Christoph A. Klein |
| Abstract |
Accumulating data suggest that metastatic dissemination often occurs early during tumour formation, but the mechanisms of early metastatic spread have not yet been addressed. Here, by studying metastasis in a HER2-driven mouse breast cancer model, we show that progesterone-induced signalling triggers migration of cancer cells from early lesions shortly after HER2 activation, but promotes proliferation in advanced primary tumour cells. The switch from migration to proliferation was regulated by increased HER2 expression and tumour-cell density involving microRNA-mediated progesterone receptor downregulation, and was reversible. Cells from early, low-density lesions displayed more stemness features, migrated more and founded more metastases than cells from dense, advanced tumours. Notably, we found that at least 80% of metastases were derived from early disseminated cancer cells. Karyotypic and phenotypic analysis of human disseminated cancer cells and primary tumours corroborated the relevance of these findings for human metastatic dissemination. |
X Demographics
The data shown below were collected from the profiles of 244 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 62 | 25% |
| United Kingdom | 17 | 7% |
| France | 9 | 4% |
| Canada | 8 | 3% |
| Australia | 6 | 2% |
| India | 6 | 2% |
| Spain | 4 | 2% |
| Netherlands | 4 | 2% |
| Argentina | 3 | 1% |
| Other | 37 | 15% |
| Unknown | 88 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 139 | 57% |
| Scientists | 82 | 34% |
| Practitioners (doctors, other healthcare professionals) | 15 | 6% |
| Science communicators (journalists, bloggers, editors) | 8 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 873 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | <1% |
| United States | 3 | <1% |
| France | 1 | <1% |
| Italy | 1 | <1% |
| Australia | 1 | <1% |
| Germany | 1 | <1% |
| Mexico | 1 | <1% |
| Netherlands | 1 | <1% |
| Japan | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 858 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 201 | 23% |
| Researcher | 156 | 18% |
| Student > Master | 94 | 11% |
| Student > Bachelor | 65 | 7% |
| Student > Doctoral Student | 63 | 7% |
| Other | 128 | 15% |
| Unknown | 166 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 242 | 28% |
| Agricultural and Biological Sciences | 166 | 19% |
| Medicine and Dentistry | 129 | 15% |
| Immunology and Microbiology | 31 | 4% |
| Engineering | 25 | 3% |
| Other | 89 | 10% |
| Unknown | 191 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 323. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 February 2023.
All research outputs
#106,042
of 25,775,807 outputs
Outputs from Nature
#7,230
of 98,706 outputs
Outputs of similar age
#2,297
of 423,358 outputs
Outputs of similar age from Nature
#146
of 885 outputs
Altmetric has tracked 25,775,807 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,706 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.7. This one has done particularly well, scoring higher than 92% of its peers.
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We're also able to compare this research output to 885 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.