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FOXO3 is essential for CD44 expression in pancreatic cancer cells

Overview of attention for article published in Oncogene, November 2016
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (67th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
1 tweeter
patent
1 patent

Citations

dimensions_citation
30 Dimensions

Readers on

mendeley
33 Mendeley
Title
FOXO3 is essential for CD44 expression in pancreatic cancer cells
Published in
Oncogene, November 2016
DOI 10.1038/onc.2016.426
Pubmed ID
Authors

M Kumazoe, M Takai, J Bae, S Hiroi, Y Huang, K Takamatsu, Y Won, M Yamashita, S Hidaka, S Yamashita, S Yamada, M Murata, S Tsukamoto, H Tachibana

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal types of cancer and the 5-year survival rate is only 5%. Several studies have suggested that cancer stem cells (CSCs) are thought to be involved in recurrence and metastasis and so it is essential to establish an approach targeting CSCs. Here we have demonstrated that cyclic guanosine monophosphate (cGMP) suppressed CD44 expression and the properties of CSCs in PDAC. Microarray analysis suggested that cGMP inhibited Forkhead box O3 (FOXO3), which is known as a tumor suppressor. Surprisingly, our data demonstrated that FOXO3 is essential for CD44 expression and the properties of CSCs. Our data also indicated that patients with high FOXO3 activation signatures had poor prognoses. This evidence suggested that cGMP induction and FOXO3 inhibition could be ideal candidates for pancreatic CSC.Oncogene advance online publication, 28 November 2016; doi:10.1038/onc.2016.426.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 18%
Researcher 5 15%
Student > Ph. D. Student 5 15%
Student > Master 3 9%
Student > Doctoral Student 2 6%
Other 6 18%
Unknown 6 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 13 39%
Agricultural and Biological Sciences 5 15%
Medicine and Dentistry 3 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Unspecified 1 3%
Other 2 6%
Unknown 7 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2018.
All research outputs
#4,268,022
of 14,799,206 outputs
Outputs from Oncogene
#2,949
of 8,661 outputs
Outputs of similar age
#121,432
of 382,083 outputs
Outputs of similar age from Oncogene
#65
of 112 outputs
Altmetric has tracked 14,799,206 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 8,661 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 382,083 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 112 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.