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Synchronous long-term oscillations in a synthetic gene circuit

Overview of attention for article published in Nature, October 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

news
3 news outlets
blogs
3 blogs
twitter
109 tweeters
wikipedia
2 Wikipedia pages
googleplus
3 Google+ users

Citations

dimensions_citation
141 Dimensions

Readers on

mendeley
519 Mendeley
citeulike
3 CiteULike
Title
Synchronous long-term oscillations in a synthetic gene circuit
Published in
Nature, October 2016
DOI 10.1038/nature19841
Pubmed ID
Authors

Laurent Potvin-Trottier, Nathan D. Lord, Glenn Vinnicombe, Johan Paulsson

Abstract

Synthetically engineered genetic circuits can perform a wide variety of tasks but are generally less accurate than natural systems. Here we revisit the first synthetic genetic oscillator, the repressilator, and modify it using principles from stochastic chemistry in single cells. Specifically, we sought to reduce error propagation and information losses, not by adding control loops, but by simply removing existing features. We show that this modification created highly regular and robust oscillations. Furthermore, some streamlined circuits kept 14 generation periods over a range of growth conditions and kept phase for hundreds of generations in single cells, allowing cells in flasks and colonies to oscillate synchronously without any coupling between them. Our results suggest that even the simplest synthetic genetic networks can achieve a precision that rivals natural systems, and emphasize the importance of noise analyses for circuit design in synthetic biology.

Twitter Demographics

The data shown below were collected from the profiles of 109 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 519 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 <1%
France 2 <1%
United Kingdom 1 <1%
Sweden 1 <1%
China 1 <1%
Spain 1 <1%
Japan 1 <1%
Germany 1 <1%
Unknown 507 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 163 31%
Student > Bachelor 77 15%
Researcher 73 14%
Student > Master 62 12%
Student > Doctoral Student 28 5%
Other 61 12%
Unknown 55 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 167 32%
Agricultural and Biological Sciences 136 26%
Engineering 46 9%
Physics and Astronomy 34 7%
Chemistry 15 3%
Other 59 11%
Unknown 62 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 111. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2020.
All research outputs
#216,180
of 17,362,547 outputs
Outputs from Nature
#14,296
of 79,634 outputs
Outputs of similar age
#6,259
of 277,390 outputs
Outputs of similar age from Nature
#409
of 1,032 outputs
Altmetric has tracked 17,362,547 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 79,634 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 89.4. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,390 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1,032 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.