↓ Skip to main content

Synchronous long-term oscillations in a synthetic gene circuit

Overview of attention for article published in Nature, October 2016
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

Mentioned by

news
4 news outlets
blogs
3 blogs
twitter
105 tweeters
wikipedia
3 Wikipedia pages
googleplus
3 Google+ users

Citations

dimensions_citation
200 Dimensions

Readers on

mendeley
582 Mendeley
citeulike
3 CiteULike
Title
Synchronous long-term oscillations in a synthetic gene circuit
Published in
Nature, October 2016
DOI 10.1038/nature19841
Pubmed ID
Authors

Laurent Potvin-Trottier, Nathan D. Lord, Glenn Vinnicombe, Johan Paulsson

Abstract

Synthetically engineered genetic circuits can perform a wide variety of tasks but are generally less accurate than natural systems. Here we revisit the first synthetic genetic oscillator, the repressilator, and modify it using principles from stochastic chemistry in single cells. Specifically, we sought to reduce error propagation and information losses, not by adding control loops, but by simply removing existing features. We show that this modification created highly regular and robust oscillations. Furthermore, some streamlined circuits kept 14 generation periods over a range of growth conditions and kept phase for hundreds of generations in single cells, allowing cells in flasks and colonies to oscillate synchronously without any coupling between them. Our results suggest that even the simplest synthetic genetic networks can achieve a precision that rivals natural systems, and emphasize the importance of noise analyses for circuit design in synthetic biology.

Twitter Demographics

The data shown below were collected from the profiles of 105 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 582 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
France 2 <1%
Sweden 1 <1%
Germany 1 <1%
China 1 <1%
United Kingdom 1 <1%
Japan 1 <1%
Spain 1 <1%
Unknown 571 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 169 29%
Student > Bachelor 91 16%
Researcher 77 13%
Student > Master 69 12%
Student > Doctoral Student 30 5%
Other 68 12%
Unknown 78 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 187 32%
Agricultural and Biological Sciences 138 24%
Engineering 48 8%
Physics and Astronomy 37 6%
Chemistry 17 3%
Other 70 12%
Unknown 85 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 115. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2021.
All research outputs
#258,836
of 20,582,425 outputs
Outputs from Nature
#15,521
of 86,168 outputs
Outputs of similar age
#6,343
of 290,698 outputs
Outputs of similar age from Nature
#401
of 1,032 outputs
Altmetric has tracked 20,582,425 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 86,168 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 96.5. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,698 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1,032 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.