An aged immune system drives senescence and ageing of solid organs

https://t.co/YhuNtZtntf ErccはDNA除去修復にかかわるタンパクで、ノックアウトは早期老化phenotypeを示す。免疫細胞特異的なErcc KOも免疫細胞の細胞老化と老化phenotypeを呈し、さらにErcc KOからWTでsplenocyte transferをするだけでも同様に老化が促進される。Nature, 2021.

RT @MaverickNY: Currently reading a great review by @MattYousefzadeh on immunosenescence, or the ageing of the immune system. While obvious…

Currently reading a great review by @MattYousefzadeh on immunosenescence, or the ageing of the immune system. While obviously relevant to the elderly, there are also important parallels to cancer as well, particularly in the context of immunotherapy: https

Late to the game but found this paper fascinating — it’s about how immunosenescence (aging of the immune system) drives systemic aging (in non-lymphoid organs) https://t.co/y9Fjl2hHGg

RT @keisuke4713: コロナ https://t.co/6fBUX7N0gz DNA損傷、前駆状態停止、SASP、ERストレスがコロナIPFで線維形成⬆ 肺移植 https://t.co/WkFcv6sKsh 老化の解明:癌とSASP https://t.co/…

コロナ https://t.co/6fBUX7N0gz DNA損傷、前駆状態停止、SASP、ERストレスがコロナIPFで線維形成⬆ 肺移植 https://t.co/WkFcv6sKsh 老化の解明:癌とSASP https://t.co/F39j682PKU 老化が腫瘍形成に及ぼす影響 元の細胞と問題組織で決まる 老化免疫→固形臓器と全身老化⬆ https://t.co/W3Juog54zw

RT @SinaiImmunol: Senescent immune cells are particularly pesky, contributing to loss of immune function with aging and wreaking havoc in o…

RT @SinaiImmunol: Senescent immune cells are particularly pesky, contributing to loss of immune function with aging and wreaking havoc in o…

An aged immune system drives senescence and ageing of solid organs https://t.co/veFtQLHEYN

Senescent immune cells are particularly pesky, contributing to loss of immune function with aging and wreaking havoc in organs throughout the body, according to this cool study of inflammaging by @MattYousefzadeh… https://t.co/Ix8whMUH0f

RT @MateMaus: Do we age due to the diminishing capacity of our immune system to eliminate damaged (senescent) cells from our organs? Three…

RT @vita_dao: And we are LIVE!✨ Longevity Journal Club S2 E4 - Your defenses might make you old 🏠Co-host: @FanONegative & @JasonColasanti…

RT @vita_dao: And we are LIVE!✨ Longevity Journal Club S2 E4 - Your defenses might make you old 🏠Co-host: @FanONegative & @JasonColasanti…

RT @vita_dao: And we are LIVE!✨ Longevity Journal Club S2 E4 - Your defenses might make you old 🏠Co-host: @FanONegative & @JasonColasanti…

Hmmm

RT @vita_dao: And we are LIVE!✨ Longevity Journal Club S2 E4 - Your defenses might make you old 🏠Co-host: @FanONegative & @JasonColasanti…

Join us here 👇 https://t.co/Baz1i5LBfb

RT @vita_dao: And we are LIVE!✨ Longevity Journal Club S2 E4 - Your defenses might make you old 🏠Co-host: @FanONegative & @JasonColasanti…

RT @vita_dao: And we are LIVE!✨ Longevity Journal Club S2 E4 - Your defenses might make you old 🏠Co-host: @FanONegative & @JasonColasanti…

RT @vita_dao: And we are LIVE!✨ Longevity Journal Club S2 E4 - Your defenses might make you old 🏠Co-host: @FanONegative & @JasonColasanti…

And we are LIVE!✨ Longevity Journal Club S2 E4 - Your defenses might make you old 🏠Co-host: @FanONegative & @JasonColasanti 👤Guest: @MattYousefzadeh We are discussing our guest's latest Nature paper: https://t.co/qAogvoPEp8 Join us👇 https://t.co

RT @JasonColasanti: Looking forward to this one! Really interesting story about how this Nature paper ‘accidentally’ came about. Tune in to…

We will be discussing our guest's latest Nature paper: https://t.co/VJjnDccdC7

https://t.co/2TRlZOUxBl https://t.co/V71yRUQWZ4

RT @vita_dao: Vitalians, new Journal Club episode next week!💛 Journal Club S2 E4 - Your defenses might make you old 🏠Co-host: @FanONegativ…

RT @vita_dao: Vitalians, new Journal Club episode next week!💛 Journal Club S2 E4 - Your defenses might make you old 🏠Co-host: @FanONegativ…

RT @vita_dao: Vitalians, new Journal Club episode next week!💛 Journal Club S2 E4 - Your defenses might make you old 🏠Co-host: @FanONegativ…

RT @vita_dao: Vitalians, new Journal Club episode next week!💛 Journal Club S2 E4 - Your defenses might make you old 🏠Co-host: @FanONegativ…

RT @vita_dao: Vitalians, new Journal Club episode next week!💛 Journal Club S2 E4 - Your defenses might make you old 🏠Co-host: @FanONegativ…

RT @JasonColasanti: Looking forward to this one! Really interesting story about how this Nature paper ‘accidentally’ came about. Tune in to…

Looking forward to this one! Really interesting story about how this Nature paper ‘accidentally’ came about. Tune in to find out 😉

Vitalians, new Journal Club episode next week!💛 Journal Club S2 E4 - Your defenses might make you old 🏠Co-host: @FanONegative and @JasonColasanti 👤Guest: @MattYousefzadeh We will be discussing our guest's latest Nature paper: https://t.co/VJjnDccdC7 ht

@OliveChirper @vita_dao @AaronLongevity It isn't available yet, but I will let you know when it is. Next episode will be 7th of November at 19:00 UTC also in Twitter Spaces. We will be discussing with @MattYousefzadeh his latest paper https://t.co/r39gh8Cw

@MattYousefzadeh @mkaeberlein How much is known about how much of the effect of rapamycin (in vivo, broadly for various markers of health) is mediated by the immune system? Thinking of https://t.co/e75DSl8ZN0

RT @Transnetyx: Researchers from @iBAM_UMN, the Department of Biochemistry at @umncbs and collaborators demonstrate that a senescent immune…

Researchers from @iBAM_UMN, the Department of Biochemistry at @umncbs and collaborators demonstrate that a senescent immune system has a causal role in driving systemic ageing and unveil a potential therapeutic target. https://t.co/TUVYaQKM0m #research #a

“The treatment of Vav-iCre+/−;Ercc1−/fl mice with rapamycin reduced markers of senescence in immune cells and improved immune function11,12. These data demonstrate that an aged,”@Blagosklonny

RT @agingdoc1: Great talk* Matt @MattYousefzadeh @ 2021 Barshop Conf, enjoyed it & the Q&A (nice pic to end it on)! I agree using F1 was…

RT @agingdoc1: Great talk* Matt @MattYousefzadeh @ 2021 Barshop Conf, enjoyed it & the Q&A (nice pic to end it on)! I agree using F1 was…

RT @agingdoc1: Great talk* Matt @MattYousefzadeh @ 2021 Barshop Conf, enjoyed it & the Q&A (nice pic to end it on)! I agree using F1 was…

RT @agingdoc1: Great talk* Matt @MattYousefzadeh @ 2021 Barshop Conf, enjoyed it & the Q&A (nice pic to end it on)! I agree using F1 was…

RT @agingdoc1: Great talk* Matt @MattYousefzadeh @ 2021 Barshop Conf, enjoyed it & the Q&A (nice pic to end it on)! I agree using F1 was…

RT @agingdoc1: Great talk* Matt @MattYousefzadeh @ 2021 Barshop Conf, enjoyed it & the Q&A (nice pic to end it on)! I agree using F1 was…

Great talk* Matt @MattYousefzadeh @ 2021 Barshop Conf, enjoyed it & the Q&A (nice pic to end it on)! I agree using F1 was better (vs C57BL/6J)- and yes many good "happy accidents"🐭 * An aged immune system drives senescence and ageing of solid or

RT @longevitywiki: Now, This Is Something That We Must Address To Accomplish Healthy Longevity 👇 https://t.co/gS9V86HLom #Longevity #Agin…

RT @longevitywiki: Now, This Is Something That We Must Address To Accomplish Healthy Longevity 👇 https://t.co/gS9V86HLom #Longevity #Agin…

Now, This Is Something That We Must Address To Accomplish Healthy Longevity 👇 https://t.co/gS9V86HLom #Longevity #Aging #AntiAging #HealthyLiving #AgingResearch #Immunity

Among the papers featured @metabesity this week. It's not too late to register (free): https://t.co/ZYOQvsq74z

RT @brunovellas: An aged immune system drives senescence and ageing of solid organs | Nature https://t.co/x0TS3euAU1

RT @davidjglassMD: Very interesting paper... also another sign of publishing being broken (two years between submission and publication...…

Exposure to pollutants, increased free-radical damage speeds up aging https://t.co/vRtvYE1LP0 https://t.co/V1ED5aCKa5 https://t.co/yPfLhR6L66

How Is Your Immune System Doing? 🥦🥝🧄🥗 #ImmuneSystem #Healthylifestyle #Longevity #Senescence #Aging https://t.co/gS9V86HLom

RT @brunovellas: An aged immune system drives senescence and ageing of solid organs | Nature https://t.co/x0TS3euAU1

RT @brunovellas: An aged immune system drives senescence and ageing of solid organs | Nature https://t.co/x0TS3euAU1

RT @brunovellas: An aged immune system drives senescence and ageing of solid organs | Nature https://t.co/x0TS3euAU1

An aged immune system drives senescence and ageing of solid organs | Nature https://t.co/x0TS3euAU1

RT @agingdoc1: An aged immune system drives senescence and ageing of solid organs In @nature, nice work Matt @MattYousefzadeh, Laura, and…

See the full study here: https://t.co/1YNBl5Huz0

RT @UMNresearch: #UMN researchers & other find that an aged immune system has a causal role in driving systemic ageing and therefore repres…

RT @NathanielEDavid: As immune system ages, it loses its ability to (somehow) get rid of senescent cells throughout your body. How cool!…

RT @MattYousefzadeh: Favorite paper of the week! https://t.co/lgnjmE6TDH

RT @aginghighlights: An aged immune system drives senescence and ageing of solid organs https://t.co/uFbinE7wbe

RT @srigsri23: An aged immune system drives senescence and ageing of solid organs https://t.co/VoL85W7xq3

An aged immune system drives senescence and ageing of solid organs https://t.co/VoL85W7xq3

Nature:An aged immune system drives senescence and ageing of solid organs https://t.co/3dYURrooab Nature:暴露在污染物中,增加的自由基损伤会加速衰老 紫外线､香烟雾､工业化学品等致自由基产生,损害DNA和组织,加速衰老｡本文为抗衰老学､延年益寿的基础医学研究论文｡ https://t.co/JppJJlYoDh

@Blagosklonny https://t.co/Hkn10QJcT9

An aged immune system drives senescence and ageing of solid organs - Nature https://t.co/m0W8efmDbZ #immunesystem #senescence #fightaging

See the full study here: https://t.co/E1rpiZavDu

#UMN researchers & other find that an aged immune system has a causal role in driving systemic ageing and therefore represents a key therapeutic target to extend healthy aging. @umnmedschool #aging

For some interesting broader context @MattYousefzadeh has recently shown that an aged immune system can drive senescence in the aorta (we didn't look at senescence in our study but should have!) https://t.co/st2gwYukgk

“Exposure to pollutants, increased free-radical damage speeds up aging, per WVU-led study” Yousefzadeh MJ et al (2021). An aged immune system drives senescence and ageing of solid organs. Nature. 2021 Jun;594(7861):100-105 https://t.co/4NpfNa7In3 https://t

RT @heniek_htw: Immune System & Aging ➡️ These data demonstrate that an aged, senescent immune system has a causal role in driving system…

Immune System & Aging ➡️ These data demonstrate that an aged, senescent immune system has a causal role in driving systemic ageing and therefore represents a key therapeutic target to extend healthy ageing. 👇 https://t.co/6I9tJlAPBM

In genetically modified mice, "an aged #ImmuneSystem [that is, missing a crucial DNA repair protein] drives senescence & #ageing of solid organs", but treatment with #rapamycin "reduced markers of #senescence in immune #cells & improved immune fu

@rachelkratofil https://t.co/AJ0JvNSEXM

17th, Jun, 2021 邊見抄読 ・Vav-creで造血細胞/血管内皮細胞特異的にDNA修復に必要な酵素Ercc1をKOすると、造血細胞の細胞老化が早まり、さらに臓器の老化も早まる ・老化した脾細胞を輸血すると、臓器・個体の老化が早まる https://t.co/vl57CKuGkU

An aged immune system drives senescence and ageing of solid organs https://t.co/iSUUt4JpQv

RT @delirious_dr: @Cunningham_Colm @markgbaxter Of course my bias lies here!😉https://t.co/rQ9osHsNno

@Cunningham_Colm @markgbaxter Of course my bias lies here!😉https://t.co/rQ9osHsNno

RT @RyanBethencourt: Ageing of the immune system contributes to the morbidity and mortality of the elderly, we're getting closer to underst…

RT @RyanBethencourt: Ageing of the immune system contributes to the morbidity and mortality of the elderly, we're getting closer to underst…

RT @RyanBethencourt: Ageing of the immune system contributes to the morbidity and mortality of the elderly, we're getting closer to underst…

Ageing of the immune system contributes to the morbidity and mortality of the elderly, we're getting closer to understanding aging (and how to slow it/reverse it) https://t.co/BCnKapWQuc

One of the papers discussed. Great read. https://t.co/2S6s63NRfI

RT @NatMetabolism: #NatMetabPicks | In @nature, Laura Niedernhofer, Paul Robbins, @MattYousefzadeh & Rafael Flores (@iBAM_UMN) demonstrate…

RT @NatMetabolism: #NatMetabPicks | In @nature, Laura Niedernhofer, Paul Robbins, @MattYousefzadeh & Rafael Flores (@iBAM_UMN) demonstrate…

RT @NatMetabolism: #NatMetabPicks | In @nature, Laura Niedernhofer, Paul Robbins, @MattYousefzadeh & Rafael Flores (@iBAM_UMN) demonstrate…

RT @NatMetabolism: #NatMetabPicks | In @nature, Laura Niedernhofer, Paul Robbins, @MattYousefzadeh & Rafael Flores (@iBAM_UMN) demonstrate…

RT @NatMetabolism: #NatMetabPicks | In @nature, Laura Niedernhofer, Paul Robbins, @MattYousefzadeh & Rafael Flores (@iBAM_UMN) demonstrate…

#NatMetabPicks | In @nature, Laura Niedernhofer, Paul Robbins, @MattYousefzadeh & Rafael Flores (@iBAM_UMN) demonstrate that an aged immune system promotes senescence and aging of organs. https://t.co/Ay9GlaqXPc

An #aged #immunesystem drives #senescence and #ageing of #solidorgans: The treatment of Vav-iCre+/−;Ercc1−/fl mice with #rapamycin reduced markers of senescence in immune cells and improved immune function https://t.co/7gE7T58BHv

An aged immune system drives senescence and ageing of solid organs | Nature https://t.co/l1XUOlqBef

https://t.co/W44eHwRdkX

RT @mmw_lmw: An #Aged_ImmuneSystem | drives #Senescence and ageing of solid organs | Laura Niedernhofer @UMNews https://t.co/Cb7qJVN18w htt…

An aged immune system drives senescence and ageing of solid organs. The treatment of mice with rapamycin reduced markers of senescence in immune cells and improved immune function. https://t.co/qEPyW8RMiV

RT @mmw_lmw: An #Aged_ImmuneSystem | drives #Senescence and ageing of solid organs | Laura Niedernhofer @UMNews https://t.co/Cb7qJVN18w htt…

RT @mmw_lmw: An #Aged_ImmuneSystem | drives #Senescence and ageing of solid organs | Laura Niedernhofer @UMNews https://t.co/Cb7qJVN18w htt…

RT @mmw_lmw: An #Aged_ImmuneSystem | drives #Senescence and ageing of solid organs | Laura Niedernhofer @UMNews https://t.co/Cb7qJVN18w htt…

RT @mmw_lmw: An #Aged_ImmuneSystem | drives #Senescence and ageing of solid organs | Laura Niedernhofer @UMNews https://t.co/Cb7qJVN18w htt…

An aged immune system drives senescence and ageing of solid organs | Nature https://t.co/RsX2F3VIr6