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Acute effects of ferumoxytol on regulation of renal hemodynamics and oxygenation

Overview of attention for article published in Scientific Reports, July 2016
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Title
Acute effects of ferumoxytol on regulation of renal hemodynamics and oxygenation
Published in
Scientific Reports, July 2016
DOI 10.1038/srep29965
Pubmed ID
Authors

Kathleen Cantow, Andreas Pohlmann, Bert Flemming, Fabienne Ferrara, Sonia Waiczies, Dirk Grosenick, Thoralf Niendorf, Erdmann Seeliger

Abstract

The superparamagnetic iron oxide nanoparticle ferumoxytol is increasingly used as intravascular contrast agent in magnetic resonance imaging (MRI). This study details the impact of ferumoxytol on regulation of renal hemodynamics and oxygenation. In 10 anesthetized rats, a single intravenous injection of isotonic saline (used as volume control) was followed by three consecutive injections of ferumoxytol to achieve cumulative doses of 6, 10, and 41 mg Fe/kg body mass. Arterial blood pressure, renal blood flow, renal cortical and medullary perfusion and oxygen tension were continuously measured. Regulation of renal hemodynamics and oxygenation was characterized by dedicated interventions: brief periods of suprarenal aortic occlusion, hypoxia, and hyperoxia. None of the three doses of ferumoxytol resulted in significant changes in any of the measured parameters as compared to saline. Ferumoxytol did not significantly alter regulation of renal hemodynamics and oxygenation as studied by aortic occlusion and hypoxia. The only significant effect of ferumoxytol at the highest dose was a blunting of the hyperoxia-induced increase in arterial pressure. Taken together, ferumoxytol has only marginal effects on the regulation of renal hemodynamics and oxygenation. This makes ferumoxytol a prime candidate as contrast agent for renal MRI including the assessment of renal blood volume fraction.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 7%
Unknown 13 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 21%
Researcher 3 21%
Student > Master 3 21%
Student > Bachelor 1 7%
Lecturer 1 7%
Other 0 0%
Unknown 3 21%
Readers by discipline Count As %
Physics and Astronomy 4 29%
Medicine and Dentistry 2 14%
Biochemistry, Genetics and Molecular Biology 1 7%
Nursing and Health Professions 1 7%
Computer Science 1 7%
Other 3 21%
Unknown 2 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2016.
All research outputs
#20,336,031
of 22,881,154 outputs
Outputs from Scientific Reports
#105,636
of 123,609 outputs
Outputs of similar age
#317,800
of 363,722 outputs
Outputs of similar age from Scientific Reports
#3,061
of 3,674 outputs
Altmetric has tracked 22,881,154 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 123,609 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 3,674 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.