The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer | Nature Medicine https://t.co/2CgjzfGQlN
Nice story from the Australian team! So then AR antagonists would not be the right strategy for AR+ breast cancer.
Alpelisib, fulvestrant, oxandrolone trial? @VasanNeil @Neil_Iyengar
The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer | Nature Medicine | Great insight towards AR function in ER+ BrCa from Aussie led science @DrTheresaHickey #WayneTilley https://t.co/AH7RtUgK91
RT @NatureMedicine: Functional interplay of androgen and estrogen in ER positive #breastcancer unveils a tumor supperssor role for androgen…
RT @DrZouaghi: Nature Medicine: Interaction fonctionnelle des androgènes et des œstrogènes chez ER positif #breastcancer dévoile un rôle de…
Nature Medicine: Interaction fonctionnelle des androgènes et des œstrogènes chez ER positif #breastcancer dévoile un rôle de suppresseur de tumeur pour le récepteur androgène et souligne le potentiel thérapeutique des agonistes AR pour les patients.
RT @NatureMedicine: Functional interplay of androgen and estrogen in ER positive #breastcancer unveils a tumor supperssor role for androgen…
Functional interplay of androgen and estrogen in ER positive #breastcancer unveils a tumor supperssor role for androgen receptor and underscores the therapeutic potential of AR agonists for patients. https://t.co/QdTiUK3gR7 #cancer #epigenetics https://
RT @DanielJDrucker: Evidence that the Androgen Receptor has a tumor suppressor role in ER-positive #breastcancer and support AR agonism as…
Interesting. Any evidence that ER might play a converse role in AR-dependent prostate cancers?
Evidence that the Androgen Receptor has a tumor suppressor role in ER-positive #breastcancer and support AR agonism as the optimal AR-directed treatment strategy, revealing a rational therapeutic opportunity @NatureMedicine https://t.co/MxpIqAWg71
Delighted to see this impactful work published! Congrats @drmcrl @DrTheresaHickey @WayneTilley12, honoured to have contributed to this wonderful study!
RT @drmcrl: Excited to present our new study published in @NatureMedicine today (https://t.co/UIa9EmqOe0), showing that androgen receptor a…
”Mechanistically, agonist activation of AR altered the genomic distribution of ER and essential co-activators (p300, SRC-3), resulting in repression of ER-regulated cell cycle genes and upregulation of AR target genes, including known tumor suppressors.” h