れました。ER陽性、HER2陰性の進行性または転移性乳がんを患う閉経後の女性136人を対象に、AR刺激薬エノボサーム(enobosarm)の有効性と安全性を評価した結果、エノボサームは顕著な抗腫瘍活性を示し、患者の忍容性は良好で、生活の質に悪影響を与えたり男性化症状を引き起こhttps://t.co/wBn7hdG01j
The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer | Nature Medicine https://t.co/MIOPQOfvV0
RT @NatureMedicine: To raise awareness for #breastcancer awareness month, here is a translational study on the role of #androgen receptor a…
RT @NatureMedicine: To raise awareness for #breastcancer awareness month, here is a translational study on the role of #androgen receptor a…
RT @NatureMedicine: To raise awareness for #breastcancer awareness month, here is a translational study on the role of #androgen receptor a…
The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer https://t.co/oSqFYkNl2e https://t.co/NG6ZcreIXw
Interesting! How about the other way around: the role of estrogen receptor in androgen receptor-positive prostate cancer? How about castration-resistant prostate cancer (CRPC)? 🧐
RT @NatureMedicine: To raise awareness for #breastcancer awareness month, here is a translational study on the role of #androgen receptor a…
RT @NatureMedicine: To raise awareness for #breastcancer awareness month, here is a translational study on the role of #androgen receptor a…
To raise awareness for #breastcancer awareness month, here is a translational study on the role of #androgen receptor as a #tumorsuppressor in #estrogen receptor-positive breast cancer #breastcancerawareness #Notimetowaste https://t.co/QdTiUK3gR7
7 “easily distracted”: Lange https://t.co/KOiuiKqmbx
へえ、という感じで、読めばわかりそうだけどトリネガのAR陽性乳がんではドライバーになるものがあると思うけど、それとはどういう関係性があるんだろ
RT @NatureMedicine: Functional interplay of androgen and #estrogen in ER positive #breastcancer unveils a tumor suppressor role for androge…
RT @NatureMedicine: Functional interplay of androgen and #estrogen in ER positive #breastcancer unveils a tumor suppressor role for androge…
Functional interplay of androgen and #estrogen in ER positive #breastcancer unveils a tumor suppressor role for androgen receptor and underscores the therapeutic potential of AR agonists for patients @drtheresahickey @drmcrl https://t.co/QdTiUK3gR7
I am going through a follow-up paper by the same group in today's #APaperADay. In this @NatureMedicine article using clinically relevant panel of cell-line and patient-derived models, the authors demonstrate that AR has a tumor suppressor role in ER+ BrCa.
RT @NatureMedicine: Functional interplay of androgen and estrogen in ER positive #breastcancer unveils a tumor suppressor role for androgen…
Functional interplay of androgen and estrogen in ER positive #breastcancer unveils a tumor suppressor role for androgen receptor and underscores the therapeutic potential of AR agonists for patients @DrTheresaHickey #BreastCancerAwarenessMonth https://t.co
RT @sachiefsci: @NatureMedicine subscribers can download the paper: “The androgen receptor is a tumor suppressor in estrogen receptor–posit…
@NatureMedicine subscribers can download the paper: “The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer” at https://t.co/27Kl8yLFLt Brilliant work from a global team! 👏 #StateOfScience
RT @NatureMedicine: Functional interplay of androgen and estrogen in ER positive #breastcancer unveils a tumor supperssor role for androgen…
The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer | Nature Medicine https://t.co/PeTH88LqCP
$VKTX Nature article mentioning Enobosarm ( $VERA ) and essentially VK5211 is better. https://t.co/j7KSbhO74z
RT @dralexswarbrick: So glad to see this important collaborative work published today. The androgen receptor is a tumour suppressor in ER+…
RT @BarbMarte: new out in Nature Medicine https://t.co/sDGLUAiTmr
new out in Nature Medicine https://t.co/sDGLUAiTmr
RT @Xemio_org: Un estudio publicado en @nature confirma que el receptor de andrógenos (hormonas masculinas) tiene un papel supresor de tum…
RT @Xemio_org: Un estudio publicado en @nature confirma que el receptor de andrógenos (hormonas masculinas) tiene un papel supresor de tum…
Un estudio publicado en @nature confirma que el receptor de andrógenos (hormonas masculinas) tiene un papel supresor de tumores en el #cáncerdemama Receptor de Estrógeno positivo. Consulta los resultados del estudio en https://t.co/wDaSsIgCZj #breastc
RT @drmcrl: Excited to present our new study published in @NatureMedicine today (https://t.co/UIa9EmqOe0), showing that androgen receptor a…
RT @cancermedic: 1 Delighted to see this key study published @NatureMedicine shows androgen receptor activation is an effective treatment…
RT @cancermedic: 1 Delighted to see this key study published @NatureMedicine shows androgen receptor activation is an effective treatment…
RT @cancermedic: 1 Delighted to see this key study published @NatureMedicine shows androgen receptor activation is an effective treatment…
RT @rikdrprof: Fabulous work and important implications. Congrats @DrTheresaHickey @drmcrl https://t.co/8hrUL1oQSV
Grande scoperta sperimentale (non clinica) pubblicata su Nature Medicine. Riguarda l’attivazione del recettore degli androgeni (AR) nella cura al cancro della mammella. Fino ad oggi la terapia farmacologica si concentrava sul recettore degli estrogeni (ER)
Fabulous work and important implications. Congrats @DrTheresaHickey @drmcrl
RT @EllisLab_: The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer | Nature Medicine | Great insight to…
The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer. https://t.co/UbM87Zz4rm
RT @CMMetastasico: 🔬🙌🏼 Excelente noticia 👇🏻 @DraAnaCasas #másinvestigaciónparamásvida
RT @DraAnaCasas: 🔺Magnifica oportunidad, activación de AR en #CancerMamaMetastasico RH+ resistente a tto. endocrino Esperemos resultados E…
@Dr_RShatsky @DrAttai @stales @BZavaletaMD @DrSGraff @NicoleKuderer @maryam_lustberg @Dr_Dana @doctorkarpoff @DrSusanLove @DrSharonBober why do you think about the recent paper discussing the role of the androgen receptor and the use of androgen agonists?
Celebrating both my first tweet and the publication from our lab below, also summarised well in this 3 min cartoon: https://t.co/wl2NAiMZOi 🎉
WOW !!!
WOW !!!
いいかげん入手しないとな
RT @drmcrl: @DRMCRL @DrTheresaHickey @WayneTilley12 thank our many collaborators and funding agencies for contributions to our new study in…
RT @NatRevClinOncol: Data from preclinical models indicate that AR is a tumour suppressor in ER+ breast cancer, & activation (not suppressi…
Great study @NatureMedicine! Very clear and straightforward! https://t.co/TZ61UBujXo
#RT Functional interplay of sex hormones in estrogen receptor–positive breast cancer unveils the therapeutic potential of androgen receptor agonists, according to a NatureMedicine paper. https://t.co/ZBpV0kieyL https://t.co/OJw127HXxM
Over time, some ER+ breast cancers develop resistance to anti-estrogen therapies. This research is reviving interest in androgens for this difficult clinical situation. #breastcancer #breast #cancer https://t.co/qss4oCrK7S
RT @NatureMedicine: Functional interplay of androgen and estrogen in ER positive #breastcancer unveils a tumor supperssor role for androgen…
@charlotte_arce @Pourquoidocteur Donc pour les gens qui savent lire une étude scientifique et l'anglais : https://t.co/c7FDdpVUcL Il s'agit bien des femmes à cancer ER+ (pas HER+), type qui est le plus répandu (75% des cas totaux), pas forcément très agres
The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer https://t.co/Q6v34ZYnFd
RT @NatRevClinOncol: Data from preclinical models indicate that AR is a tumour suppressor in ER+ breast cancer, & activation (not suppressi…
RT @NatRevClinOncol: Data from preclinical models indicate that AR is a tumour suppressor in ER+ breast cancer, & activation (not suppressi…
RT @NatRevClinOncol: Data from preclinical models indicate that AR is a tumour suppressor in ER+ breast cancer, & activation (not suppressi…
RT @CyrilPedia: 'Mechanistically, agonist activation of AR altered the genomic distribution of ER and essential co-activators (p300, SRC-3)…
RT @AdamSharpMedOnc: This is both excellent and important; long wondered the implications of targeting AR in breast cancer; and this adds t…
Everything is always more complicated than first thought. Enzalutamide first showed promise in breast cancer before flaming out. Not to mention the AR splice variants that also show up in many AR+ breast cancers - they disrupt normal AR signalling.
'Mechanistically, agonist activation of AR altered the genomic distribution of ER and essential co-activators (p300, SRC-3), resulting in repression of ER-regulated cell cycle genes and upregulation of AR target genes, including known tumor suppressors.' h
RT @NatRevClinOncol: Data from preclinical models indicate that AR is a tumour suppressor in ER+ breast cancer, & activation (not suppressi…
Love seeing these exciting studies coming out of the lab where I completed part of my PhD work. Very interesting read!
RT @maryam_lustberg: #bcsm #breastcancer #epigenetics @NatureMedicine
RT @NatRevClinOncol: Data from preclinical models indicate that AR is a tumour suppressor in ER+ breast cancer, & activation (not suppressi…
RT @NatRevClinOncol: Data from preclinical models indicate that AR is a tumour suppressor in ER+ breast cancer, & activation (not suppressi…
RT @NatRevClinOncol: Data from preclinical models indicate that AR is a tumour suppressor in ER+ breast cancer, & activation (not suppressi…
RT @NatRevClinOncol: Data from preclinical models indicate that AR is a tumour suppressor in ER+ breast cancer, & activation (not suppressi…
RT @cancermedic: 1 Delighted to see this key study published @NatureMedicine shows androgen receptor activation is an effective treatment…
RT @cancermedic: 1 Delighted to see this key study published @NatureMedicine shows androgen receptor activation is an effective treatment…
RT @DraAnaCasas: 🔺Magnifica oportunidad, activación de AR en #CancerMamaMetastasico RH+ resistente a tto. endocrino Esperemos resultados E…
RT @NatRevClinOncol: Data from preclinical models indicate that AR is a tumour suppressor in ER+ breast cancer, & activation (not suppressi…
Data from preclinical models indicate that AR is a tumour suppressor in ER+ breast cancer, & activation (not suppression) of AR improves therapy. A gene signature of AR activity positively predicted survival in multiple clinical ER+ #breastcancer cohor
Nueva evidencia sobre el papel positivo de los andrógenos en el tratamiento del #CancerDeMama.
🔬🙌🏼 Excelente noticia 👇🏻 @DraAnaCasas #másinvestigaciónparamásvida
RT @DraAnaCasas: 🔺Magnifica oportunidad, activación de AR en #CancerMamaMetastasico RH+ resistente a tto. endocrino Esperemos resultados E…
🔺Magnifica oportunidad, activación de AR en #CancerMamaMetastasico RH+ resistente a tto. endocrino Esperemos resultados EC con Enobosarm+Palbociclib https://t.co/Zyp1h9hMgj en @nature @CMMetastasico @asociacioninvi @FECMA_ @_SOLTI @GEICAM @_SEOM @pfiz
The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer | Nature Medicine https://t.co/HdOMN7oWYB
RT @drmcrl: Excited to present our new study published in @NatureMedicine today (https://t.co/UIa9EmqOe0), showing that androgen receptor a…
RT @dralexswarbrick: So glad to see this important collaborative work published today. The androgen receptor is a tumour suppressor in ER+…
RT @dralexswarbrick: So glad to see this important collaborative work published today. The androgen receptor is a tumour suppressor in ER+…
RT @dralexswarbrick: So glad to see this important collaborative work published today. The androgen receptor is a tumour suppressor in ER+…
RT @drmcrl: Excited to present our new study published in @NatureMedicine today (https://t.co/UIa9EmqOe0), showing that androgen receptor a…
The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer https://t.co/Tzha3rzIyR
RT @obogler: A very interesting new paper in @NatureMedicine demonstrates, in models, that selective androgen agonists can suppress #breast…
RT @dralexswarbrick: So glad to see this important collaborative work published today. The androgen receptor is a tumour suppressor in ER+…
ARでサプレスされる乳がんもあると。。トリネガの一部ではARでドライブされる乳がんもある。。
RT @obogler: A very interesting new paper in @NatureMedicine demonstrates, in models, that selective androgen agonists can suppress #breast…
A very interesting new paper in @NatureMedicine demonstrates, in models, that selective androgen agonists can suppress #breastcancer including in hormone therapy resistant cells. What about #malebreastcancer ? https://t.co/GA1iosIE5C
RT @drmcrl: Excited to present our new study published in @NatureMedicine today (https://t.co/UIa9EmqOe0), showing that androgen receptor a…
RT @NatureMedicine: Functional interplay of androgen and estrogen in ER positive #breastcancer unveils a tumor supperssor role for androgen…
RT @EllisLab_: The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer | Nature Medicine | Great insight to…
Great to see this out finally. Good job.
RT @douglasagibson: Excellent study highlighting the importance of understanding the balance and interaction between both androgens and est…
RT @Dr_RShatsky: This is potentially very promising new translational research for ER+ breast cancer. Time to move beyond the mice. Let the…
RT @DanielJDrucker: Evidence that the Androgen Receptor has a tumor suppressor role in ER-positive #breastcancer and support AR agonism as…
RT @cancermedic: 1 Delighted to see this key study published @NatureMedicine shows androgen receptor activation is an effective treatment…
That's an interesting and important finding.
RT @EvaMay_CRM: Informative animated @YouTube video on how androgen receptors in ER+ #breast cancer have hampered clinical application of a…