| Title |
Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts
|
|---|---|
| Published in |
British Journal of Cancer, March 2009
|
| DOI | 10.1038/sj.bjc.6605011 |
| Pubmed ID | |
| Authors |
K Huhtinen, P Suvitie, J Hiissa, J Junnila, J Huvila, H Kujari, M Setälä, P Härkki, J Jalkanen, J Fraser, J Mäkinen, A Auranen, M Poutanen, A Perheentupa |
| Abstract |
Human epididymal secretory protein E4 (HE4, also known as WAP four-disulphide core domain protein 2) is a new promising biomarker for ovarian cancer but its specificity against ovarian endometriotic cysts is only superficially known. We, thus, analysed serum HE4 concentrations together with a tumour marker CA125 in serum samples of women diagnosed with various types of endometriosis, endometrial cancer or ovarian cancer, and in samples from healthy controls. The mean serum concentration of HE4 was significantly higher in serum samples of patients with both endometrial (99.2 pM, P<0.001) and ovarian (1125.4 pM, P<0.001) cancer but not with ovarian endometriomas (46.0 pM) or other types of endometriosis (45.5 pM) as compared with healthy controls (40.5 pM). The serum CA125 concentrations were elevated in patients with ovarian cancer, advanced endometriosis with peritoneal or deep lesions, or ovarian endometriomas, but not in the patients with endometrial cancer. The microarray results revealed that the mRNA expression of the genes encoding HE4 and CA125 reflected the serum protein concentrations. Taken together, measuring both HE4 and CA125 serum concentrations increases the accuracy of ovarian cancer diagnosis and provides valuable information to discriminate ovarian tumours from ovarian endometriotic cysts. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Hungary | 1 | <1% |
| Canada | 1 | <1% |
| Netherlands | 1 | <1% |
| Spain | 1 | <1% |
| Egypt | 1 | <1% |
| Unknown | 126 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 14% |
| Researcher | 18 | 14% |
| Student > Bachelor | 15 | 11% |
| Other | 12 | 9% |
| Student > Master | 11 | 8% |
| Other | 27 | 20% |
| Unknown | 32 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 58 | 44% |
| Agricultural and Biological Sciences | 15 | 11% |
| Biochemistry, Genetics and Molecular Biology | 11 | 8% |
| Chemistry | 2 | 2% |
| Immunology and Microbiology | 2 | 2% |
| Other | 9 | 7% |
| Unknown | 36 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 March 2022.
All research outputs
#1,947,501
of 25,837,817 outputs
Outputs from British Journal of Cancer
#890
of 11,165 outputs
Outputs of similar age
#5,740
of 108,994 outputs
Outputs of similar age from British Journal of Cancer
#5
of 80 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,165 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 108,994 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.