| Title |
Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease
|
|---|---|
| Published in |
Nature Reviews Drug Discovery, June 2016
|
| DOI | 10.1038/nrd.2016.89 |
| Pubmed ID | |
| Authors |
Robert G. Gourdie, Stefanie Dimmeler, Peter Kohl |
| Abstract |
Our understanding of the functions of cardiac fibroblasts has moved beyond their roles in heart structure and extracellular matrix generation and now includes their contributions to paracrine, mechanical and electrical signalling during ontogenesis and normal cardiac activity. Fibroblasts also have central roles in pathogenic remodelling during myocardial ischaemia, hypertension and heart failure. As key contributors to scar formation, they are crucial for tissue repair after interventions including surgery and ablation. Novel experimental approaches targeting cardiac fibroblasts are promising potential therapies for heart disease. Indeed, several existing drugs act, at least partially, through effects on cardiac connective tissue. This Review outlines the origins and roles of fibroblasts in cardiac development, homeostasis and disease; illustrates the involvement of fibroblasts in current and emerging clinical interventions; and identifies future targets for research and development. |
X Demographics
The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 7 | 28% |
| United States | 3 | 12% |
| Japan | 2 | 8% |
| Colombia | 1 | 4% |
| Denmark | 1 | 4% |
| Ireland | 1 | 4% |
| China | 1 | 4% |
| Egypt | 1 | 4% |
| Iraq | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 7 | 28% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 44% |
| Scientists | 9 | 36% |
| Science communicators (journalists, bloggers, editors) | 3 | 12% |
| Practitioners (doctors, other healthcare professionals) | 2 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 399 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| Switzerland | 1 | <1% |
| Germany | 1 | <1% |
| Saudi Arabia | 1 | <1% |
| China | 1 | <1% |
| Spain | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 390 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 106 | 27% |
| Researcher | 59 | 15% |
| Student > Master | 35 | 9% |
| Student > Bachelor | 34 | 9% |
| Student > Doctoral Student | 24 | 6% |
| Other | 62 | 16% |
| Unknown | 79 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 79 | 20% |
| Biochemistry, Genetics and Molecular Biology | 72 | 18% |
| Agricultural and Biological Sciences | 63 | 16% |
| Engineering | 27 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 18 | 5% |
| Other | 55 | 14% |
| Unknown | 85 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 99. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2023.
All research outputs
#432,623
of 26,017,215 outputs
Outputs from Nature Reviews Drug Discovery
#193
of 3,691 outputs
Outputs of similar age
#8,590
of 374,664 outputs
Outputs of similar age from Nature Reviews Drug Discovery
#3
of 57 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,691 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.1. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 374,664 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.