| Title |
Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis
|
|---|---|
| Published in |
Arthritis Research & Therapy, June 2016
|
| DOI | 10.1186/s13075-016-1037-7 |
| Pubmed ID | |
| Authors |
Sofia E. M. Andersson, Tove Eneljung, Sara Tengvall, Pernilla Jirholt, Anna Stern, Louise Henningsson, Bibo Liang, Katrin Thorarinsdottir, Jan Kihlberg, Rikard Holmdahl, Inga-Lill Mårtensson, Kenth Gustafsson, Inger Gjertsson |
| Abstract |
The mechanisms underlying tolerance induction and maintenance in autoimmune arthritis remain elusive. In a mouse model of rheumatoid arthritis, collagen type II (CII)-induced arthritis, we explore the contribution of B cells to antigen-specific tolerance. To generate expression of the CII-peptide specifically on B-cell major histocompatibility complex type II, lentiviral-based gene therapy including a B-cell-specific Igk promoter was used. Presentation of the CII-peptide on B cells significantly reduced the frequency and severity of arthritis as well as the serum levels of CII -specific IgG antibodies. Further, both frequency and suppressive function of regulatory T cells were increased in tolerized mice. Adoptive transfer of regulatory T cells from tolerized mice to naïve mice ameliorated the development of CII-induced arthritis. Our data suggest that endogenous presentation of the CII-peptide on B cells is one of the key contributors to arthritis tolerance induction and maintenance. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 18 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 17% |
| Researcher | 2 | 11% |
| Librarian | 1 | 6% |
| Student > Ph. D. Student | 1 | 6% |
| Other | 1 | 6% |
| Other | 2 | 11% |
| Unknown | 8 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Business, Management and Accounting | 2 | 11% |
| Immunology and Microbiology | 2 | 11% |
| Medicine and Dentistry | 2 | 11% |
| Social Sciences | 1 | 6% |
| Biochemistry, Genetics and Molecular Biology | 1 | 6% |
| Other | 2 | 11% |
| Unknown | 8 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2018.
All research outputs
#19,944,994
of 25,374,917 outputs
Outputs from Arthritis Research & Therapy
#2,814
of 3,381 outputs
Outputs of similar age
#268,077
of 368,454 outputs
Outputs of similar age from Arthritis Research & Therapy
#47
of 58 outputs
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