RT @quervain_de: @BohacekLab Take a look at this study: https://t.co/pwB4zG4LFS Medium effect size of 0.5 of SSRIs at optimal doses compare…
@BohacekLab Take a look at this study: https://t.co/pwB4zG4LFS Medium effect size of 0.5 of SSRIs at optimal doses compared to placebo.
@DavidJuurlink but, yes, of course there is likely a dose response curve - a common trope that ssris do not have a dose respone curve (we typically have to get to 80mg for OCD, for example) (https://t.co/sgKcUZrtqX) https://t.co/TXbzTwBrsG
@psybalazs @PloederlM @eturnermd1 @BenColagiuri @Toshi_FRKW @ReadReadj @EikoFried @MattBurkeMD We reported week-by-week data here: https://t.co/r9SEXj2DMA and here: https://t.co/uDVQOkIrMZ This should give you a good hint. If you need more data, I second
@tkaiser_science @md_pier See here: https://t.co/1M1nXodNVB
@tkaiser_science @EikoFried @CVolkmannMD @HengartnerMP @SteHoman @PloederlM (see https://t.co/cv6O4GrfM9). One take on that would be that most of those patients can still improve on average 2 points and that those among those ~25% that really can't improve
「#SSRI は4-8週目から有効性が発現する」と云われるが(図2 [https://t.co/KfF8pYH4u2])、それは #統計学的有意性 の話であって、被検者数が多い週毎の #メタ解析 では2週目から有効(#統計学的有意)と示されてある[https://t.co/E1BCJYlVFu]。
RT @PloederlM: Found several studies using patient-level data across trials, e.g. this one for different SSRIs and placebo https://t.co/MuL…
固定用量試験のメタ解析により3つのSSRIの用量依存性と迅速な抗うつ効果の発現が判明した 2016/7 @f_hieronymus 〜 #HDRS=#HAMD 全17項目の合計得点よりも #抗うつ効果 をより高い感度で検出できることが証明された単一項目 #抑うつ気分 のみを主要な効果変数に指定した。 https://t.co/HQhK3bxT4D
@Sven_Roman 4.) (skamlös reklam) ES påverkas kraftigt av vilka symtom som ingår i skattningen (https://t.co/1VQ3Jx7Wxx), huruvida patienterna redan uppvisar dessa symtom eller ej (https://t.co/uzOiSVg09U), vilka doser som ges (https://t.co/MefLk33pAU), val
Found several studies using patient-level data across trials, e.g. this one for different SSRIs and placebo https://t.co/MuLilJ0P4u https://t.co/Pw7uyurvyo
@markhoro @Mental_Elf @ReadReadj @suzypuss @And_Cipriani @ParianteSPILab @jf_moore @CEP_UK @tony_kendrick @wendyburn This paper? https://t.co/l0GYTIx2Zj I like the nuance, and agree re fx-and 0.5 effect size. I agree if fx of a drug occurs in a certain way
M-A: Low doses of CIT, SER, PXT are less effective than higher ones in MDD https://t.co/NEJSGk7azP
先行メタ分析研究で抗うつ薬の効果が過小評価されていたのは容量が少ないから。容量を増やすと効果が高まる。ただし、これ以上効果が高まらない上限もある。メタ分析。A mega-analysis of fixed-dose trials …https://t.co/j6HTCUwgkD