| Title |
Copper regulates cyclic-AMP-dependent lipolysis
|
|---|---|
| Published in |
Nature Chemical Biology, June 2016
|
| DOI | 10.1038/nchembio.2098 |
| Pubmed ID | |
| Authors |
Lakshmi Krishnamoorthy, Joseph A Cotruvo, Jefferson Chan, Harini Kaluarachchi, Abigael Muchenditsi, Venkata S Pendyala, Shang Jia, Allegra T Aron, Cheri M Ackerman, Mark N Vander Wal, Timothy Guan, Lukas P Smaga, Samouil L Farhi, Elizabeth J New, Svetlana Lutsenko, Christopher J Chang |
| Abstract |
Cell signaling relies extensively on dynamic pools of redox-inactive metal ions such as sodium, potassium, calcium and zinc, but their redox-active transition metal counterparts such as copper and iron have been studied primarily as static enzyme cofactors. Here we report that copper is an endogenous regulator of lipolysis, the breakdown of fat, which is an essential process in maintaining body weight and energy stores. Using a mouse model of genetic copper misregulation, in combination with pharmacological alterations in copper status and imaging studies in a 3T3-L1 white adipocyte model, we found that copper regulates lipolysis at the level of the second messenger, cyclic AMP (cAMP), by altering the activity of the cAMP-degrading phosphodiesterase PDE3B. Biochemical studies of the copper-PDE3B interaction establish copper-dependent inhibition of enzyme activity and identify a key conserved cysteine residue in a PDE3-specific loop that is essential for the observed copper-dependent lipolytic phenotype. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 30% |
| United Kingdom | 1 | 5% |
| Australia | 1 | 5% |
| Canada | 1 | 5% |
| Spain | 1 | 5% |
| Czechia | 1 | 5% |
| Saudi Arabia | 1 | 5% |
| Germany | 1 | 5% |
| Unknown | 7 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 55% |
| Scientists | 5 | 25% |
| Practitioners (doctors, other healthcare professionals) | 4 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 159 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 159 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 45 | 28% |
| Researcher | 29 | 18% |
| Student > Master | 14 | 9% |
| Student > Bachelor | 12 | 8% |
| Student > Doctoral Student | 10 | 6% |
| Other | 22 | 14% |
| Unknown | 27 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 43 | 27% |
| Biochemistry, Genetics and Molecular Biology | 40 | 25% |
| Agricultural and Biological Sciences | 16 | 10% |
| Medicine and Dentistry | 9 | 6% |
| Immunology and Microbiology | 4 | 3% |
| Other | 12 | 8% |
| Unknown | 35 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 274. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2019.
All research outputs
#126,776
of 24,903,209 outputs
Outputs from Nature Chemical Biology
#31
of 3,318 outputs
Outputs of similar age
#2,583
of 347,806 outputs
Outputs of similar age from Nature Chemical Biology
#2
of 54 outputs
Altmetric has tracked 24,903,209 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,318 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 347,806 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.