RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
This may partly explain the lowered melanoma survival of APOE2 carriers (established by @benostendorf) and be relevant to APOE2's protective effect in Alzheimer's. Currently exploring this mechanism more so I'll save the tweetorial for the revised version!
RT @benostendorf: (2/11) In the #tavazoielab we previously found that APOE variants, notorious for their role in Alzheimer’s, modulate anti…
RT @benostendorf: (2/11) In the #tavazoielab we previously found that APOE variants, notorious for their role in Alzheimer’s, modulate anti…
RT @benostendorf: (2/11) In the #tavazoielab we previously found that APOE variants, notorious for their role in Alzheimer’s, modulate anti…
RT @benostendorf: (2/11) In the #tavazoielab we previously found that APOE variants, notorious for their role in Alzheimer’s, modulate anti…
W #tavazoielab stwierdzono wcześniej, że warianty APOE, znane z roli w chorobie Alzheimera, modulują odporność na czerniaka (https://t.co/1i6CnvzhA9 ). Biorąc pod uwagę heterogeniczność wyników COVID19, zastanawiano się: czy warianty APOE w różny sposób mo
(2/11) In the #tavazoielab we previously found that APOE variants, notorious for their role in Alzheimer’s, modulate anti-melanoma immunity (https://t.co/s2dsQQjuZf). Given the heterogeneity of COVID19 outcomes we wondered: do APOE variants differentially
@rust_ruslan There is a paper showing that ApoE variants play an opposite role in melanoma : ApoE4 protects against tumor progression and has better survival while ApoE2 has a poor outcome https://t.co/4xwxrXMgzF
RT @DermalCell: Studying the APOE gene, @SohailTavazoie and scientists at @RockefellerUniv published in @NatureMedicine and report that APO…
RT @NatureMedicine: Heritable APOE variants in patients with melanoma influence anti-tumor immunity and modulate metastatic progression and…
@Carkauf23 @ArainHirra Not sure if you've seen this study, but it seems like the APOE4 variant is also protective in melanomas! This may also have something to do with decrease in vascularization, since most cancers up-regulate angiogenesis factors? ht
Common germline variants of the human APOE gene modulate melanoma progression and survival. https://t.co/cpNO7Z1WTe https://t.co/HhRhTnDMEB
RT @NatureMedicine: Heritable APOE variants in patients with melanoma influence anti-tumor immunity and modulate metastatic progression and…
RT @SohailTavazoie: Thx @MartinGuilliams! Re. clinical targeting: see Masoud's Cell paper: ApoE activation by RGENIX LXR agonist RGX-104 de…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @SohailTavazoie: Thx @MartinGuilliams! Re. clinical targeting: see Masoud's Cell paper: ApoE activation by RGENIX LXR agonist RGX-104 de…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @SohailTavazoie: Thx @MartinGuilliams! Re. clinical targeting: see Masoud's Cell paper: ApoE activation by RGENIX LXR agonist RGX-104 de…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
Thx @MartinGuilliams! Re. clinical targeting: see Masoud's Cell paper: ApoE activation by RGENIX LXR agonist RGX-104 depletes MDSCs & induces T cells in mice & patients https://t.co/TnMoBHTIeZ, & Lim/Mita et al., @AACR: durable RGX-104 tumor re
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
RT @MartinGuilliams: In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab…
In this Preview we combine TREM2 articles @CellCellPress with the APOE variants article @NatureMedicine: Tavazoie lab https://t.co/pAsL7l21cP + Colonna lab https://t.co/Ce5QDAATOP + @IdoAmitLab https://t.co/tL5IJOtenG = Major APOE-TREM2 axis in Cancer h
RT @cancer_evolve: MELANOMA: germline variation at the human APOE locus, known to be a modifier of risk for neurodegenerative disease, has…
MELANOMA: germline variation at the human APOE locus, known to be a modifier of risk for neurodegenerative disease, has now been linked to both patient outcomes and responses to immunotherapy in melanoma. https://t.co/1WrmX1oAtB
RT @NatureMedicine: Heritable APOE variants in patients with melanoma influence anti-tumor immunity and modulate metastatic progression and…
RT @benostendorf: Thank you @NatureRevCancer for highlighting our work on APOE germline variants in melanoma progression and anti-tumor imm…
RT @benostendorf: Thank you @NatureRevCancer for highlighting our work on APOE germline variants in melanoma progression and anti-tumor imm…
RT @benostendorf: Thank you @NatureRevCancer for highlighting our work on APOE germline variants in melanoma progression and anti-tumor imm…
RT @benostendorf: Thank you @NatureRevCancer for highlighting our work on APOE germline variants in melanoma progression and anti-tumor imm…
RT @benostendorf: Thank you @NatureRevCancer for highlighting our work on APOE germline variants in melanoma progression and anti-tumor imm…
Thank you @NatureRevCancer for highlighting our work on APOE germline variants in melanoma progression and anti-tumor immunity! This is a great summary if you want to dip your toe in the water - for the full paper see here: https://t.co/7NBhVGdVhr
Apolipoproteins have defined roles in a myriad of diseases- from #Alzheimer’s to #atheroscolosis. Now researchers from @RockerfellerUniv link ApoE variants to #melanoma
APOE4はアルツハイマー病や動脈硬化のリスクファクターだが、がんに対しては抑制的な働きをしているかも、というお話 Common germline variants of the human APOE gene modulate melanoma progression and survival https://t.co/Xhr3Ctrej6
RT @NatureMedicine: Heritable APOE variants in patients with melanoma influence anti-tumor immunity and modulate metastatic progression and…
RT @betenoire1: Cancer metastasis vs Alzheimer’s — ApoE4 has opposite effects on disease risk. Not a desirable tradeoff! This is original a…
RT @BrundinPatrik: Prior evidence of links between APOE and #synuclein pathology, as well as an association between #parkinson and #melanom…
Pre-existing hereditary genetics can impact progression and survival outcomes of a future malignancy https://t.co/VCKlROOlm0 APOE genotype as a biomarker for melanoma outcome and therapeutic response
“Common Germline Variants of the Human APOE Gene Modulate Melanoma Progression and Survival” Ostendorf BN [..] Tavazoie SF. (bioRxiv 2019-03-13) Nat Med 2020-05-25. https://t.co/ofJ8ryopss [in JPN] https://t.co/kZthkMs6Kr
Risk of metastasis is determined by tumor cell-inherent factors & host microenvironment. Interesting (but not surprising): Host microenvironmental factors are influenced by pre-existing genetic host variables, in this case APOE variants. Paper in Nat M
RT @EricTopol: Until now we knew the common, infamous APOE4 allele⬆️ #Alzheimers risk. Today we learn of its potential for revving up the i…
RT @M_SuarezCalvet: APOEe4 - bad for #Alzheimers , good for #Cancer 🤔🤔 in @NatureMedicine 👇 https://t.co/nB2bLq9Fih
RT @NatureMedicine: Heritable APOE variants in patients with melanoma influence anti-tumor immunity and modulate metastatic progression and…
RT @NatureMedicine: Heritable APOE variants in patients with melanoma influence anti-tumor immunity and modulate metastatic progression and…
RT @M_SuarezCalvet: APOEe4 - bad for #Alzheimers , good for #Cancer 🤔🤔 in @NatureMedicine 👇 https://t.co/nB2bLq9Fih
RT @yochai_wolf: This one is pretty amazing
RT @benostendorf: 1/ The “Alzheimer’s gene” APOE modulates melanoma outcome - our paper out today in @NatureMedicine 🥳 Thanks a ton to ever…
RT @M_SuarezCalvet: APOEe4 - bad for #Alzheimers , good for #Cancer 🤔🤔 in @NatureMedicine 👇 https://t.co/nB2bLq9Fih
RT @NatureMedicine: Heritable APOE variants in patients with melanoma influence anti-tumor immunity and modulate metastatic progression and…
RT @NatureMedicine: Heritable APOE variants in patients with melanoma influence anti-tumor immunity and modulate metastatic progression and…
RT @NatureMedicine: Heritable APOE variants in patients with melanoma influence anti-tumor immunity and modulate metastatic progression and…
RT @NatureMedicine: Heritable APOE variants in patients with melanoma influence anti-tumor immunity and modulate metastatic progression and…
RT @NatureMedicine: Heritable APOE variants in patients with melanoma influence anti-tumor immunity and modulate metastatic progression and…
RT @NatureMedicine: Heritable APOE variants in patients with melanoma influence anti-tumor immunity and modulate metastatic progression and…
RT @NatureMedicine: Heritable APOE variants in patients with melanoma influence anti-tumor immunity and modulate metastatic progression and…
Heritable APOE variants in patients with melanoma influence anti-tumor immunity and modulate metastatic progression and response to immunotherapy. @SohailTavazoie @RockefellerUniv @benostendorf @JanaBilanovic https://t.co/XCI7tOw39j
@john_damianos …and *better* melanoma outcomes 🤯 https://t.co/Pp3bLCw65H h/t @fairfaxlab
RT @M_SuarezCalvet: APOEe4 - bad for #Alzheimers , good for #Cancer 🤔🤔 in @NatureMedicine 👇 https://t.co/nB2bLq9Fih
RT @SohailTavazoie: Here's full PDF link: https://t.co/HBZzjtPOEy @NatureMedicine Ben's paper from #TavazoieLab @RockefellerUniv reveals a…
RT @M_SuarezCalvet: APOEe4 - bad for #Alzheimers , good for #Cancer 🤔🤔 in @NatureMedicine 👇 https://t.co/nB2bLq9Fih
Common germline variants of the human APOE gene modulate melanoma progression and survival. https://t.co/uRbKN964oV https://t.co/w8T2i3kdvy
RT @NatRevClinOncol: Common germline variants of the human APOE4 and APOE2 genes confer favourable and poor outcomes, respectively, in mice…
Common germline variants of the human APOE4 and APOE2 genes confer favourable and poor outcomes, respectively, in mice and pts with melanoma (including with ICI), contrary to their effects in Alzheimer’s disease: https://t.co/EgzEdnW3h1 #melsm #ImmunoOnc
RT @GraeffJohannes: Trade-off between Alzheimer’s and cancer? Interesting study in @NatureMedicine. Common germline variants of the huma…
Common germline variants of the human APOE gene modulate melanoma progression and survival. Nat Med #Alzheimers https://t.co/Vg1uyETG8e
#Study reveals first evidence inherited genetics can drive #cancer's spread @RockefellerUniv Scientists have long struggled to understand what drives a tumour to seed itself elsewhere in the body #Oncology #metastases https://t.co/iEnAUzTFqW & https
RT @narayan_pri: APOE variants just keep surprising me! https://t.co/8mdqWAyg0Q
APOE variants just keep surprising me! https://t.co/8mdqWAyg0Q
RT @KaletaLab: Another example for the antagonism between #Cancer and degenerative diseases we found in #aging. APOe4 is bad in #Alzheimer…
RT @betenoire1: Cancer metastasis vs Alzheimer’s — ApoE4 has opposite effects on disease risk. Not a desirable tradeoff! This is original a…
RT @ApoEdscvr: Common germline variants of the human APOE gene modulate melanoma progression and survival | Nature Medicine https://t.co/Iz…
RT @SohailTavazoie: 1/ Congrats to Ben Ostendorf and our #TavazoieLab at @RockefellerUniv for revealing a hereditary genetic basis to canc…
RT @M_SuarezCalvet: APOEe4 - bad for #Alzheimers , good for #Cancer 🤔🤔 in @NatureMedicine 👇 https://t.co/nB2bLq9Fih
RT @M_SuarezCalvet: APOEe4 - bad for #Alzheimers , good for #Cancer 🤔🤔 in @NatureMedicine 👇 https://t.co/nB2bLq9Fih
Great work from @benostendorf on Apoe variants and melanoma metastasis
RT @M_SuarezCalvet: APOEe4 - bad for #Alzheimers , good for #Cancer 🤔🤔 in @NatureMedicine 👇 https://t.co/nB2bLq9Fih
RT @SohailTavazoie: 1/ Congrats to Ben Ostendorf and our #TavazoieLab at @RockefellerUniv for revealing a hereditary genetic basis to canc…
RT @EricTopol: Until now we knew the common, infamous APOE4 allele⬆️ #Alzheimers risk. Today we learn of its potential for revving up the i…