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Congrats to my former Celgene colleagues for publishing this co-crystal structure, further convincing evidence of the involvement of cereblon-mediated SALL4 degradation in thalidomide teratogenicity! #birthdefectsresearch
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RT @NatureSMB: The structure of the SALL4-Pomalidomide-Cereblon-DDB1 complex provides insights for rational design of cereblon binding drug…
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RT @NatureSMB: The structure of the SALL4-Pomalidomide-Cereblon-DDB1 complex provides insights for rational design of cereblon binding drug…
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RT @NatureSMB: The structure of the SALL4-Pomalidomide-Cereblon-DDB1 complex provides insights for rational design of cereblon binding drug…
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RT @NatureSMB: The structure of the SALL4-Pomalidomide-Cereblon-DDB1 complex provides insights for rational design of cereblon binding drug…
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RT @NatureSMB: The structure of the SALL4-Pomalidomide-Cereblon-DDB1 complex provides insights for rational design of cereblon binding drug…
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RT @NatureSMB: The structure of the SALL4-Pomalidomide-Cereblon-DDB1 complex provides insights for rational design of cereblon binding drug…
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RT @NatureSMB: The structure of the SALL4-Pomalidomide-Cereblon-DDB1 complex provides insights for rational design of cereblon binding drug…
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RT @NatureSMB: The structure of the SALL4-Pomalidomide-Cereblon-DDB1 complex provides insights for rational design of cereblon binding drug…
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RT @NatureSMB: The structure of the SALL4-Pomalidomide-Cereblon-DDB1 complex provides insights for rational design of cereblon binding drug…
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RT @NatureSMB: The structure of the SALL4-Pomalidomide-Cereblon-DDB1 complex provides insights for rational design of cereblon binding drug…
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RT @NatureSMB: The structure of the SALL4-Pomalidomide-Cereblon-DDB1 complex provides insights for rational design of cereblon binding drug…
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RT @NatureSMB: The structure of the SALL4-Pomalidomide-Cereblon-DDB1 complex provides insights for rational design of cereblon binding drug…
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RT @NatureSMB: The structure of the SALL4-Pomalidomide-Cereblon-DDB1 complex provides insights for rational design of cereblon binding drug…
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RT @NatureSMB: The structure of the SALL4-Pomalidomide-Cereblon-DDB1 complex provides insights for rational design of cereblon binding drug…
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RT @NatureSMB: The structure of the SALL4-Pomalidomide-Cereblon-DDB1 complex provides insights for rational design of cereblon binding drug…
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RT @NatureSMB: The structure of the SALL4-Pomalidomide-Cereblon-DDB1 complex provides insights for rational design of cereblon binding drug…
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RT @NatureSMB: The structure of the SALL4-Pomalidomide-Cereblon-DDB1 complex provides insights for rational design of cereblon binding drug…
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The structure of the SALL4-Pomalidomide-Cereblon-DDB1 complex provides insights for rational design of cereblon binding drugs with reduced teratogenic risk. https://t.co/FWfOmQcl0O
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RT @somturn20: pomalidomideなどによるサリドマイド催奇形性がSALL4とcereblonと相互作用させることにより誘発することが2018年頃に分かって、「そうなんだ」と思った記憶がある。こんな相互作用してるのか。 https://t.co/vA1TK…
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pomalidomideなどによるサリドマイド催奇形性がSALL4とcereblonと相互作用させることにより誘発することが2018年頃に分かって、「そうなんだ」と思った記憶がある。こんな相互作用してるのか。 https://t.co/vA1TKzgOiu
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Crystal structure of the SALL4–pomalidomide–cereblon–DDB1 complex | Nature Structural & Molecular Biology https://t.co/FjqPkQdYMZ