| Title |
Maternal immune activation by poly(I:C) induces expression of cytokines IL-1β and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain
|
|---|---|
| Published in |
Journal of Neuroinflammation, April 2012
|
| DOI | 10.1186/1742-2094-9-83 |
| Pubmed ID | |
| Authors |
Géraldine Arrode-Brusés, Juan L Brusés |
| Abstract |
Maternal viral infection during pregnancy is associated with an increase in the incidence of psychiatric disorders with presumed neurodevelopmental origin, including autism spectrum disorders and schizophrenia. The enhanced risk for developing mental illness appears to be caused by deleterious effects of innate immune response-associated factors on the development of the central nervous system, which predispose the offspring to pathological behaviors in adolescence and adulthood. To identify the immune response-associated soluble factors that may affect central nervous system development, we examined the effect of innate immune response activation by polyriboinosinic-polyribocytidylic acid (poly(I:C)), a synthetic analogue of viral double-stranded RNA, on the expression levels of pro- and anti-inflammatory cytokines, chemokines and colony stimulating factors in fetal and postnatal mouse brain 6 h and 24 h after treatment. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 231 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| Brazil | 2 | <1% |
| United Kingdom | 2 | <1% |
| Mexico | 1 | <1% |
| Israel | 1 | <1% |
| Unknown | 222 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 53 | 23% |
| Researcher | 30 | 13% |
| Student > Master | 29 | 13% |
| Student > Bachelor | 25 | 11% |
| Student > Doctoral Student | 21 | 9% |
| Other | 37 | 16% |
| Unknown | 36 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 47 | 20% |
| Neuroscience | 42 | 18% |
| Medicine and Dentistry | 39 | 17% |
| Biochemistry, Genetics and Molecular Biology | 17 | 7% |
| Psychology | 15 | 6% |
| Other | 28 | 12% |
| Unknown | 43 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2023.
All research outputs
#20,166,456
of 25,654,806 outputs
Outputs from Journal of Neuroinflammation
#2,257
of 2,969 outputs
Outputs of similar age
#133,252
of 175,524 outputs
Outputs of similar age from Journal of Neuroinflammation
#30
of 43 outputs
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