| Title |
Prostaglandin E2 promotes intestinal tumor growth via DNA methylation
|
|---|---|
| Published in |
Nature Medicine, January 2012
|
| DOI | 10.1038/nm.2608 |
| Pubmed ID | |
| Authors |
Dianren Xia, Dingzhi Wang, Sun-Hee Kim, Hiroshi Katoh, Raymond N DuBois |
| Abstract |
Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E(2) (PGE(2)) silences certain tumor-suppressor and DNA-repair genes through DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE(2) in the promotion of tumor progression. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 29% |
| Canada | 3 | 21% |
| Japan | 1 | 7% |
| United Kingdom | 1 | 7% |
| Singapore | 1 | 7% |
| Unknown | 4 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 71% |
| Scientists | 3 | 21% |
| Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 5% |
| Germany | 1 | <1% |
| Austria | 1 | <1% |
| Denmark | 1 | <1% |
| South Africa | 1 | <1% |
| Japan | 1 | <1% |
| China | 1 | <1% |
| Unknown | 107 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 26% |
| Researcher | 30 | 25% |
| Student > Master | 15 | 13% |
| Student > Bachelor | 9 | 8% |
| Student > Doctoral Student | 7 | 6% |
| Other | 22 | 18% |
| Unknown | 5 | 4% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 44 | 37% |
| Medicine and Dentistry | 26 | 22% |
| Biochemistry, Genetics and Molecular Biology | 22 | 18% |
| Neuroscience | 5 | 4% |
| Chemistry | 5 | 4% |
| Other | 9 | 8% |
| Unknown | 8 | 7% |
Attention Score in Context
This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2019.
All research outputs
#1,433,559
of 24,022,746 outputs
Outputs from Nature Medicine
#2,915
of 8,843 outputs
Outputs of similar age
#10,125
of 252,459 outputs
Outputs of similar age from Nature Medicine
#24
of 122 outputs
Altmetric has tracked 24,022,746 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,843 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 101.6. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,459 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 122 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.