| Title |
Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery
|
|---|---|
| Published in |
Nature Nanotechnology, February 2016
|
| DOI | 10.1038/nnano.2015.342 |
| Pubmed ID | |
| Authors |
Yu Matsumoto, Joseph W. Nichols, Kazuko Toh, Takahiro Nomoto, Horacio Cabral, Yutaka Miura, R. James Christie, Naoki Yamada, Tadayoshi Ogura, Mitsunobu R. Kano, Yasuhiro Matsumura, Nobuhiro Nishiyama, Tatsuya Yamasoba, You Han Bae, Kazunori Kataoka |
| Abstract |
Enhanced permeability in tumours is thought to result from malformed vascular walls with leaky cell-to-cell junctions. This assertion is backed by studies using electron microscopy and polymer casts that show incomplete pericyte coverage of tumour vessels and the presence of intercellular gaps. However, this gives the impression that tumour permeability is static amid a chaotic tumour environment. Using intravital confocal laser scanning microscopy we show that the permeability of tumour blood vessels includes a dynamic phenomenon characterized by vascular bursts followed by brief vigorous outward flow of fluid (named 'eruptions') into the tumour interstitial space. We propose that 'dynamic vents' form transient openings and closings at these leaky blood vessels. These stochastic eruptions may explain the enhanced extravasation of nanoparticles from the tumour blood vessels, and offer insights into the underlying distribution patterns of an administered drug. |
X Demographics
The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 24% |
| Japan | 2 | 12% |
| Spain | 2 | 12% |
| France | 1 | 6% |
| Korea, Republic of | 1 | 6% |
| Unknown | 7 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 59% |
| Scientists | 5 | 29% |
| Science communicators (journalists, bloggers, editors) | 2 | 12% |
Mendeley readers
The data shown below were compiled from readership statistics for 311 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| United Kingdom | 2 | <1% |
| Australia | 1 | <1% |
| Spain | 1 | <1% |
| Taiwan | 1 | <1% |
| Unknown | 304 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 71 | 23% |
| Researcher | 45 | 14% |
| Student > Master | 35 | 11% |
| Student > Bachelor | 29 | 9% |
| Student > Doctoral Student | 16 | 5% |
| Other | 63 | 20% |
| Unknown | 52 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 49 | 16% |
| Agricultural and Biological Sciences | 34 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 31 | 10% |
| Biochemistry, Genetics and Molecular Biology | 29 | 9% |
| Materials Science | 25 | 8% |
| Other | 73 | 23% |
| Unknown | 70 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 January 2022.
All research outputs
#1,660,041
of 25,622,179 outputs
Outputs from Nature Nanotechnology
#1,324
of 3,769 outputs
Outputs of similar age
#29,883
of 413,988 outputs
Outputs of similar age from Nature Nanotechnology
#33
of 85 outputs
Altmetric has tracked 25,622,179 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,769 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.7. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 413,988 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 85 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.