| Title |
The heterogeneity of human CD127+ innate lymphoid cells revealed by single-cell RNA sequencing
|
|---|---|
| Published in |
Nature Immunology, February 2016
|
| DOI | 10.1038/ni.3368 |
| Pubmed ID | |
| Authors |
Åsa K Björklund, Marianne Forkel, Simone Picelli, Viktoria Konya, Jakob Theorell, Danielle Friberg, Rickard Sandberg, Jenny Mjösberg |
| Abstract |
Innate lymphoid cells (ILCs) are increasingly appreciated as important participants in homeostasis and inflammation. Substantial plasticity and heterogeneity among ILC populations have been reported. Here we have delineated the heterogeneity of human ILCs through single-cell RNA sequencing of several hundreds of individual tonsil CD127(+) ILCs and natural killer (NK) cells. Unbiased transcriptional clustering revealed four distinct populations, corresponding to ILC1 cells, ILC2 cells, ILC3 cells and NK cells, with their respective transcriptomes recapitulating known as well as unknown transcriptional profiles. The single-cell resolution additionally divulged three transcriptionally and functionally diverse subpopulations of ILC3 cells. Our systematic comparison of single-cell transcriptional variation within and between ILC populations provides new insight into ILC biology during homeostasis, with additional implications for dysregulation of the immune system. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 17% |
| United Kingdom | 1 | 8% |
| Spain | 1 | 8% |
| Unknown | 8 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 83% |
| Science communicators (journalists, bloggers, editors) | 2 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 577 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | <1% |
| Sweden | 3 | <1% |
| Germany | 1 | <1% |
| Switzerland | 1 | <1% |
| Greece | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 566 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 139 | 24% |
| Researcher | 119 | 21% |
| Student > Master | 70 | 12% |
| Student > Bachelor | 36 | 6% |
| Student > Doctoral Student | 32 | 6% |
| Other | 79 | 14% |
| Unknown | 102 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 134 | 23% |
| Immunology and Microbiology | 130 | 23% |
| Biochemistry, Genetics and Molecular Biology | 99 | 17% |
| Medicine and Dentistry | 54 | 9% |
| Neuroscience | 7 | 1% |
| Other | 46 | 8% |
| Unknown | 107 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 103. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2023.
All research outputs
#417,233
of 25,837,817 outputs
Outputs from Nature Immunology
#289
of 4,234 outputs
Outputs of similar age
#7,891
of 416,711 outputs
Outputs of similar age from Nature Immunology
#8
of 64 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,234 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 35.8. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 416,711 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.