| Title |
Mechanisms of epithelial fusion and repair
|
|---|---|
| Published in |
Nature Cell Biology, May 2001
|
| DOI | 10.1038/35074643 |
| Pubmed ID | |
| Authors |
Antonio Jacinto, Alfonso Martinez-Arias, Paul Martin |
| Abstract |
One of the principal functions of any epithelium in the embryonic or adult organism is to act as a self-sealing barrier layer. From the earliest stages of development, embryonic epithelia are required to close naturally occurring holes and to fuse wherever two free edges are brought together, and at the simplest level that is precisely what the epidermis must do to repair itself wherever it is damaged. Parallels can be drawn between the artificially triggered epithelial movements of wound repair and the naturally occurring epithelial movements that shape the embryo during morphogenesis. Recent in vitro and in vivo wound-healing studies and analysis of paradigm morphogenetic movements in genetically tractable embryos, like those of Drosophila and Caenorhabditis elegans, have begun to identify both the signals that initiate these movements and the cytoskeletal machinery that drives motility. We are also gaining insight into the nature of the brakes and stop signals, and the mechanisms by which the confronting epithelial sheets knit together to form a seam. |
Mendeley readers
The data shown below were compiled from readership statistics for 297 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 4 | 1% |
| United States | 2 | <1% |
| France | 2 | <1% |
| Netherlands | 1 | <1% |
| Finland | 1 | <1% |
| Switzerland | 1 | <1% |
| Canada | 1 | <1% |
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 282 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 72 | 24% |
| Researcher | 46 | 15% |
| Student > Master | 39 | 13% |
| Student > Bachelor | 21 | 7% |
| Professor | 18 | 6% |
| Other | 48 | 16% |
| Unknown | 53 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 93 | 31% |
| Biochemistry, Genetics and Molecular Biology | 60 | 20% |
| Medicine and Dentistry | 24 | 8% |
| Engineering | 20 | 7% |
| Physics and Astronomy | 12 | 4% |
| Other | 26 | 9% |
| Unknown | 62 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2020.
All research outputs
#5,713,209
of 22,846,662 outputs
Outputs from Nature Cell Biology
#2,109
of 3,826 outputs
Outputs of similar age
#11,432
of 40,161 outputs
Outputs of similar age from Nature Cell Biology
#11
of 36 outputs
Altmetric has tracked 22,846,662 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 3,826 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.2. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 40,161 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.