| Title |
microRNAs join the p53 network — another piece in the tumour-suppression puzzle
|
|---|---|
| Published in |
Nature Reviews Cancer, November 2007
|
| DOI | 10.1038/nrc2232 |
| Pubmed ID | |
| Authors |
Lin He, Xingyue He, Scott W. Lowe, Gregory J. Hannon |
| Abstract |
Several recent studies have found a conserved microRNA (miRNA) family, the miR-34s, to be direct transcriptional targets of p53. miR-34 activation can recapitulate elements of p53 activity, including induction of cell-cycle arrest and promotion of apoptosis, and loss of miR-34 can impair p53-mediated cell death. These data reinforce the growing awareness that non-coding RNAs are key players in tumour development by placing miRNAs in a central role in a well-known tumour-suppressor network. |
Mendeley readers
The data shown below were compiled from readership statistics for 274 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 3% |
| Netherlands | 2 | <1% |
| Spain | 2 | <1% |
| France | 2 | <1% |
| Switzerland | 1 | <1% |
| Italy | 1 | <1% |
| Austria | 1 | <1% |
| Germany | 1 | <1% |
| Chile | 1 | <1% |
| Other | 3 | 1% |
| Unknown | 253 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 68 | 25% |
| Student > Ph. D. Student | 64 | 23% |
| Professor > Associate Professor | 29 | 11% |
| Student > Master | 18 | 7% |
| Professor | 13 | 5% |
| Other | 47 | 17% |
| Unknown | 35 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 114 | 42% |
| Biochemistry, Genetics and Molecular Biology | 57 | 21% |
| Medicine and Dentistry | 34 | 12% |
| Neuroscience | 6 | 2% |
| Computer Science | 5 | 2% |
| Other | 19 | 7% |
| Unknown | 39 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2018.
All research outputs
#7,472,947
of 22,846,662 outputs
Outputs from Nature Reviews Cancer
#1,587
of 2,311 outputs
Outputs of similar age
#25,858
of 76,851 outputs
Outputs of similar age from Nature Reviews Cancer
#18
of 22 outputs
Altmetric has tracked 22,846,662 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,311 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.0. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 76,851 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.