RT @renesugar: Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin https://t.co/EYb7GBmGNk "SubB has a…
RT @renesugar: Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin https://t.co/EYb7GBmGNk "SubB has a…
https://t.co/EYb7GBmGNk "Thus, through regular dietary intake of red meats and milk, humans may pre-sensitise their tissues to a key virulence factor of a major pathogen that occurs sporadically in the same foods."
https://t.co/EYb7GBmGNk "Ironically, red meat and dairy products (the richest dietary sources of Neu5Gc) are the very foods that are most commonly contaminated with SubAB-producing STEC2."
https://t.co/EYb7GBmGNk "This high specificity of SubAB for Neu5Gc-terminating glycans is unique amongst bacterial toxins."
https://t.co/EYb7GBmGNk "This, together with the human lack of Neu5Gc-containing body fluid competitors, confers susceptibility to the gastrointestinal and systemic toxicities of SubAB."
https://t.co/EYb7GBmGNk "Despite human lack of Neu5Gc biosynthesis, assimilation of dietary Neu5Gc creates high-affinity receptors on human gut epithelia and kidney vasculature."
Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin https://t.co/EYb7GBmGNk "SubB has a strong preference for glycans terminating in the sialic acid N-glycolylneuraminic acid (Neu5Gc), a monosaccharide not synthesised i
Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin https://t.co/EYb7GBDJPk https://t.co/nlpZy9o8Xe
RT @biotrend: #EHEC sind Toxin produzierende E. coli, die bei Menschen zu schwersten #Nierenschäden führen — außer bei #Veganern. https://t…
#EHEC sind Toxin produzierende E. coli, die bei Menschen zu schwersten #Nierenschäden führen — außer bei #Veganern. https://t.co/V7cfmI6HGP
October 30th edition of Nature http://t.co/0g2MO8TEC1