RT @Kazuh_ideA: ALSでは、TDP-43と呼ばれるタンパク質が凝集することで、運動ニューロンが変性するという説がある。再生中の筋肉では、TDP-43が直径50-250ナノメートルの顆粒を形成し、筋再生を促している可能性を指摘。TDP-43顆粒には生理機能が備わっ…
RT @Kazuh_ideA: ALSでは、TDP-43と呼ばれるタンパク質が凝集することで、運動ニューロンが変性するという説がある。再生中の筋肉では、TDP-43が直径50-250ナノメートルの顆粒を形成し、筋再生を促している可能性を指摘。TDP-43顆粒には生理機能が備わっ…
RT @Kazuh_ideA: ALSでは、TDP-43と呼ばれるタンパク質が凝集することで、運動ニューロンが変性するという説がある。再生中の筋肉では、TDP-43が直径50-250ナノメートルの顆粒を形成し、筋再生を促している可能性を指摘。TDP-43顆粒には生理機能が備わっ…
RT @Kazuh_ideA: ALSでは、TDP-43と呼ばれるタンパク質が凝集することで、運動ニューロンが変性するという説がある。再生中の筋肉では、TDP-43が直径50-250ナノメートルの顆粒を形成し、筋再生を促している可能性を指摘。TDP-43顆粒には生理機能が備わっ…
RT @Kazuh_ideA: ALSでは、TDP-43と呼ばれるタンパク質が凝集することで、運動ニューロンが変性するという説がある。再生中の筋肉では、TDP-43が直径50-250ナノメートルの顆粒を形成し、筋再生を促している可能性を指摘。TDP-43顆粒には生理機能が備わっ…
TDP-43は多くの研究者が研究していますね 孤発性ALSだったかな
RT @Kazuh_ideA: ALSでは、TDP-43と呼ばれるタンパク質が凝集することで、運動ニューロンが変性するという説がある。再生中の筋肉では、TDP-43が直径50-250ナノメートルの顆粒を形成し、筋再生を促している可能性を指摘。TDP-43顆粒には生理機能が備わっ…
RT @Kazuh_ideA: ALSでは、TDP-43と呼ばれるタンパク質が凝集することで、運動ニューロンが変性するという説がある。再生中の筋肉では、TDP-43が直径50-250ナノメートルの顆粒を形成し、筋再生を促している可能性を指摘。TDP-43顆粒には生理機能が備わっ…
RT @Kazuh_ideA: ALSでは、TDP-43と呼ばれるタンパク質が凝集することで、運動ニューロンが変性するという説がある。再生中の筋肉では、TDP-43が直径50-250ナノメートルの顆粒を形成し、筋再生を促している可能性を指摘。TDP-43顆粒には生理機能が備わっ…
RT @Kazuh_ideA: ALSでは、TDP-43と呼ばれるタンパク質が凝集することで、運動ニューロンが変性するという説がある。再生中の筋肉では、TDP-43が直径50-250ナノメートルの顆粒を形成し、筋再生を促している可能性を指摘。TDP-43顆粒には生理機能が備わっ…
RT @Kazuh_ideA: ALSでは、TDP-43と呼ばれるタンパク質が凝集することで、運動ニューロンが変性するという説がある。再生中の筋肉では、TDP-43が直径50-250ナノメートルの顆粒を形成し、筋再生を促している可能性を指摘。TDP-43顆粒には生理機能が備わっ…
RT @Kazuh_ideA: ALSでは、TDP-43と呼ばれるタンパク質が凝集することで、運動ニューロンが変性するという説がある。再生中の筋肉では、TDP-43が直径50-250ナノメートルの顆粒を形成し、筋再生を促している可能性を指摘。TDP-43顆粒には生理機能が備わっ…
RT @Kazuh_ideA: ALSでは、TDP-43と呼ばれるタンパク質が凝集することで、運動ニューロンが変性するという説がある。再生中の筋肉では、TDP-43が直径50-250ナノメートルの顆粒を形成し、筋再生を促している可能性を指摘。TDP-43顆粒には生理機能が備わっ…
ALSでは、TDP-43と呼ばれるタンパク質が凝集することで、運動ニューロンが変性するという説がある。再生中の筋肉では、TDP-43が直径50-250ナノメートルの顆粒を形成し、筋再生を促している可能性を指摘。TDP-43顆粒には生理機能が備わっていて、量の調節の異常で凝集か。 https://t.co/3oONIEFKPa
#NIAMSCouncil Science Advance @CUBoulder: “TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.” https://t.co/GRpgBZkmgB @Nature. https://t.co/gANJlH69ga
RT @Matt_Muscle_Guy: #2. TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle. #Nature. https://t.co/TPrgp9ZfiA. An interes…
RT @Matt_Muscle_Guy: #2. TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle. #Nature. https://t.co/TPrgp9ZfiA. An interes…
#2. TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle. #Nature. https://t.co/TPrgp9ZfiA. An interesting paper highlighting potential common mechanisms of ALS/FTD RNA/protien aggregate effects on muscle. Likely commonalities with expansio
RT @NatRevRheumatol: #ResearchHighlight | TDP-43 in the muscles: friend or foe? #Myositis #InclusionBodyMyositis Read the original researc…
RT @NatRevRheumatol: #ResearchHighlight | TDP-43 in the muscles: friend or foe? #Myositis #InclusionBodyMyositis Read the original researc…
#ResearchHighlight | TDP-43 in the muscles: friend or foe? #Myositis #InclusionBodyMyositis Read the original research @nature at https://t.co/wrvvPTyUjp Read our news story here: https://t.co/2MuC0b3dMg
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle https://t.co/1hrvvisNGY
[trend] https://t.co/0uVtFS3lma with 3 stars: *Vogler TO* et al (Nature) **TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.** https://t.co/mmWbXbRCxu
RT @NilsWalterLab: So true - disease is but an aberration of a natural, necessary process - learning how it works will give us control over…
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle. https://t.co/VXw7NUJqa8
Nature ハイライト:TDP-43の集合体は正常な筋再生の際に形成されて除去される | Nature | Nature Research https://t.co/m7EY5ELR1D
So true - disease is but an aberration of a natural, necessary process - learning how it works will give us control over it, eventually - great case for foundational (i.e., basic) science! Congrats to Roy Parker from @ucboulder on great @nature ppr!
RT @NatureJapan: Nature ハイライト:TDP-43の集合体は正常な筋再生の際に形成されて除去される | Nature https://t.co/jMWjZuoWOW #神経変性
RT @NatureJapan: Nature ハイライト:TDP-43の集合体は正常な筋再生の際に形成されて除去される | Nature https://t.co/jMWjZuoWOW #神経変性
네이처 하이라이트:신경근육성 질환에서 나타나는 아밀로이드 유사 마이오-그레뉼 형성에 관여하는 TDP-43 돌연변이 https://t.co/7FnxJLWFkh
Nature ハイライト:TDP-43の集合体は正常な筋再生の際に形成されて除去される | Nature https://t.co/jMWjZuoWOW #神経変性
Nature ハイライト:TDP-43の集合体は正常な筋再生の際に形成されて除去される | Nature | Nature Research: https://t.co/EdQ67Xgulm
神経変性: TDP-43の集合体は正常な筋再生の際に形成されて除去される (Nature Research) https://t.co/99EjfV4qUi
RT @RobbySeaborne: Identification of TDP-43 for a playing a role in normal Sk. muscle regeneration, but also in neuromuscular disease when…
#NIAMSResearch @cuboulder: “TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle” https://t.co/nNiIQNXVnl. Abstract only; full access requires subscription or payment. @NatureNews https://t.co/4lYSfkFzr1
RT @EricTopol: Misfolded, clumped proteins are supposed to be toxic. So what are they doing in healthy muscle cells? https://t.co/weeyYOnVK…
RNA binding protein, #TDP43, found to be an essential protein for normal skeletal muscle formation that unexpectedly forms cytoplasmic, amyloid-like oligomeric assemblies (myo-granules) during regeneration of skeletal muscle in mice and humans.
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @ShorterLab: TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle: https://t.co/8gh9VfyHhw https://t.co/wXXh3VaG5v
RT @musclecellnews: Our featured story this week- amyloids in healthy muscle: TDP-43 & RNA Form #Amyloid-Like Myo-Granules in Regenerating…
Congratulations to Tom and Josh!
Our featured story this week- amyloids in healthy muscle: TDP-43 & RNA Form #Amyloid-Like Myo-Granules in Regenerating #Muscle @nature @CUBoulder @CUAnschutz @VoglerTom @bradolwin https://t.co/vib7Qp887F https://t.co/EQU3qZuVfZ
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @ShorterLab: TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle: https://t.co/8gh9VfyHhw https://t.co/wXXh3VaG5v
Absolutely fantastic. Work from Colorado's guys @bradolwin and Roy Parker. Congratulations. Top !
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @denaturant: ALSの病巣に蓄積するTDP43凝集体は、骨格筋の形成にも働くんだそうだ。筋繊維が成熟するとこのミオ顆粒は消失する。液-液相分離したドロプレットが正義の味方で、クロスβを骨格にする凝集体が悪者だというふうな単純な分類は成り立たないんだろうな。 h…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @denaturant: ALSの病巣に蓄積するTDP43凝集体は、骨格筋の形成にも働くんだそうだ。筋繊維が成熟するとこのミオ顆粒は消失する。液-液相分離したドロプレットが正義の味方で、クロスβを骨格にする凝集体が悪者だというふうな単純な分類は成り立たないんだろうな。 h…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @denaturant: ALSの病巣に蓄積するTDP43凝集体は、骨格筋の形成にも働くんだそうだ。筋繊維が成熟するとこのミオ顆粒は消失する。液-液相分離したドロプレットが正義の味方で、クロスβを骨格にする凝集体が悪者だというふうな単純な分類は成り立たないんだろうな。 h…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @denaturant: ALSの病巣に蓄積するTDP43凝集体は、骨格筋の形成にも働くんだそうだ。筋繊維が成熟するとこのミオ顆粒は消失する。液-液相分離したドロプレットが正義の味方で、クロスβを骨格にする凝集体が悪者だというふうな単純な分類は成り立たないんだろうな。 h…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @denaturant: ALSの病巣に蓄積するTDP43凝集体は、骨格筋の形成にも働くんだそうだ。筋繊維が成熟するとこのミオ顆粒は消失する。液-液相分離したドロプレットが正義の味方で、クロスβを骨格にする凝集体が悪者だというふうな単純な分類は成り立たないんだろうな。 h…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
これちゃんと読んだ方が良い気がする。。ご紹介ありがとうございます。
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
ALSの病巣に蓄積するTDP43凝集体は、骨格筋の形成にも働くんだそうだ。筋繊維が成熟するとこのミオ顆粒は消失する。液-液相分離したドロプレットが正義の味方で、クロスβを骨格にする凝集体が悪者だというふうな単純な分類は成り立たないんだろうな。 https://t.co/kOxJAC8EAX
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @wittyremarkhere: This looks interesting: functional, amyloid-like TDP-43 aggregates in skeletal muscle. Just in case you were thinking…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
RT @nature: The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be patho…
The protein TDP-43, commonly implicated in neuromuscular diseases such as amyotrophic lateral sclerosis and thought to be pathogenic, is shown to accumulate and have a functional role in normal muscle growth and regeneration, reports a paper in Nature. htt