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SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death

Overview of attention for article published in Cell Death & Disease, September 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

news
1 news outlet
twitter
4 tweeters
wikipedia
1 Wikipedia page

Readers on

mendeley
170 Mendeley
Title
SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death
Published in
Cell Death & Disease, September 2018
DOI 10.1038/s41419-018-0917-y
Pubmed ID
Authors

Yuan Yue, Neel R. Nabar, Chong-Shan Shi, Olena Kamenyeva, Xun Xiao, Il-Young Hwang, Min Wang, John H. Kehrl

Abstract

The molecular mechanisms underlying the severe lung pathology that occurs during SARS-CoV infections remain incompletely understood. The largest of the SARS-CoV accessory protein open reading frames (SARS 3a) oligomerizes, dynamically inserting into late endosomal, lysosomal, and trans-Golgi-network membranes. While previously implicated in a non-inflammatory apoptotic cell death pathway, here we extend the range of SARS 3a pathophysiologic targets by examining its effects on necrotic cell death pathways. We show that SARS 3a interacts with Receptor Interacting Protein 3 (Rip3), which augments the oligomerization of SARS 3a helping drive necrotic cell death. In addition, by inserting into lysosomal membranes SARS 3a triggers lysosomal damage and dysfunction. Consequently, Transcription Factor EB (TFEB) translocates to the nucleus increasing the transcription of autophagy- and lysosome-related genes. Finally, SARS 3a activates caspase-1 either directly or via an enhanced potassium efflux, which triggers NLRP3 inflammasome assembly. In summary, Rip3-mediated oligomerization of SARS 3a causes necrotic cell death, lysosomal damage, and caspase-1 activation-all likely contributing to the clinical manifestations of SARS-CoV infection.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 170 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 170 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 28 16%
Researcher 26 15%
Student > Bachelor 20 12%
Student > Master 13 8%
Professor 11 6%
Other 31 18%
Unknown 41 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 49 29%
Medicine and Dentistry 21 12%
Immunology and Microbiology 16 9%
Agricultural and Biological Sciences 13 8%
Chemistry 4 2%
Other 23 14%
Unknown 44 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2020.
All research outputs
#1,591,971
of 18,929,457 outputs
Outputs from Cell Death & Disease
#214
of 5,187 outputs
Outputs of similar age
#38,181
of 287,638 outputs
Outputs of similar age from Cell Death & Disease
#13
of 198 outputs
Altmetric has tracked 18,929,457 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,187 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,638 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 198 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.