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A tissue-based draft map of the murine MHC class I immunopeptidome

Overview of attention for article published in Scientific Data, August 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Average Attention Score compared to outputs of the same age and source

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Title
A tissue-based draft map of the murine MHC class I immunopeptidome
Published in
Scientific Data, August 2018
DOI 10.1038/sdata.2018.157
Pubmed ID
Authors

Heiko Schuster, Wenguang Shao, Tobias Weiss, Patrick G.A. Pedrioli, Patrick Roth, Michael Weller, David S. Campbell, Eric W. Deutsch, Robert L. Moritz, Oliver Planz, Hans-Georg Rammensee, Ruedi Aebersold, Etienne Caron

Abstract

The large array of peptides presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules is referred to as the MHC class I immunopeptidome. Although the MHC class I immunopeptidome is ubiquitous in mammals and represents a critical component of the immune system, very little is known, in any species, about its composition across most tissues and organs in vivo. We applied mass spectrometry (MS) technologies to draft the first tissue-based atlas of the murine MHC class I immunopeptidome in health. Peptides were extracted from 19 normal tissues from C57BL/6 mice and prepared for MS injections, resulting in a total number of 28,448 high-confidence H2Db/Kb-associated peptides identified and annotated in the atlas. This atlas provides initial qualitative data to explore the tissue-specificity of the immunopeptidome and serves as a guide to identify potential tumor-associated antigens from various cancer models. Our data were shared via PRIDE (PXD008733), SysteMHC Atlas (SYSMHC00018) and SWATH Atlas. We anticipate that this unique dataset will be expanded in the future and will find wide applications in basic and translational immunology.

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The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 127 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 30 24%
Researcher 22 17%
Student > Master 14 11%
Student > Bachelor 10 8%
Student > Postgraduate 10 8%
Other 15 12%
Unknown 26 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 39 31%
Agricultural and Biological Sciences 20 16%
Immunology and Microbiology 8 6%
Medicine and Dentistry 7 6%
Chemistry 6 5%
Other 19 15%
Unknown 28 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 August 2018.
All research outputs
#4,204,521
of 23,099,576 outputs
Outputs from Scientific Data
#1,236
of 2,517 outputs
Outputs of similar age
#81,227
of 330,798 outputs
Outputs of similar age from Scientific Data
#34
of 69 outputs
Altmetric has tracked 23,099,576 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,517 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.5. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,798 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.