| Title |
Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons
|
|---|---|
| Published in |
Nature Communications, October 2015
|
| DOI | 10.1038/ncomms9512 |
| Pubmed ID | |
| Authors |
Yanmei Qi, Laura Andolfi, Flavia Frattini, Florian Mayer, Marco Lazzarino, Jing Hu |
| Abstract |
Sensing force is crucial to maintain the viability of all living cells. Despite its fundamental importance, how force is sensed at the molecular level remains largely unknown. Here we show that stomatin-like protein-3 (STOML3) controls membrane mechanics by binding cholesterol and thus facilitates force transfer and tunes the sensitivity of mechano-gated channels, including Piezo channels. STOML3 is detected in cholesterol-rich lipid rafts. In mouse sensory neurons, depletion of cholesterol and deficiency of STOML3 similarly and interdependently attenuate mechanosensitivity while modulating membrane mechanics. In heterologous systems, intact STOML3 is required to maintain membrane mechanics to sensitize Piezo1 and Piezo2 channels. In C57BL/6N, but not STOML3(-/-) mice, tactile allodynia is attenuated by cholesterol depletion, suggesting that membrane stiffening by STOML3 is essential for mechanical sensitivity. Targeting the STOML3-cholesterol association might offer an alternative strategy for control of chronic pain. |
Mendeley readers
The data shown below were compiled from readership statistics for 176 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 176 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 56 | 32% |
| Researcher | 30 | 17% |
| Student > Master | 22 | 13% |
| Student > Bachelor | 14 | 8% |
| Student > Doctoral Student | 11 | 6% |
| Other | 24 | 14% |
| Unknown | 19 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 37 | 21% |
| Biochemistry, Genetics and Molecular Biology | 35 | 20% |
| Neuroscience | 34 | 19% |
| Engineering | 16 | 9% |
| Medicine and Dentistry | 16 | 9% |
| Other | 13 | 7% |
| Unknown | 25 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 October 2015.
All research outputs
#1,165,012
of 22,830,751 outputs
Outputs from Nature Communications
#17,482
of 47,017 outputs
Outputs of similar age
#18,481
of 278,126 outputs
Outputs of similar age from Nature Communications
#285
of 759 outputs
Altmetric has tracked 22,830,751 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 47,017 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.7. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,126 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 759 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.