↓ Skip to main content

Genetic diversity of Plasmodium falciparum isolates from Baka Pygmies and their Bantu neighbours in the north of Gabon

Overview of attention for article published in Malaria Journal, October 2015
Altmetric Badge

Mentioned by

twitter
1 X user

Readers on

mendeley
36 Mendeley
Title
Genetic diversity of Plasmodium falciparum isolates from Baka Pygmies and their Bantu neighbours in the north of Gabon
Published in
Malaria Journal, October 2015
DOI 10.1186/s12936-015-0862-5
Pubmed ID
Authors

Bertrand Mvé-Ondo, Dieudonné Nkoghe, Céline Arnathau, Virginie Rougeron, Ulrich Bisvigou, Lauriane Yacka Mouele, Larson Boundenga, Patrick Durand, Eric Elguero, Simone Lemmers, Lucrèce M. Délicat-Loembet, Nancy Diamella-Moukodoum, Christophe Paupy, François Renaud, Franck Prugnolle, Benjamin Ollomo

Abstract

There have been many reports on the population genetic structure of Plasmodium falciparum from different endemic regions especially sub-Saharan Africa. However, few studies have been performed on neglected populations, such as the Pygmy populations. In this study, the population genetic structure of P. falciparum was investigated in the Baka Pygmies of Gabon and compared to that observed in neighboring villages composed mostly of Bantu farmers. A total of 342 blood samples were collected from 170 Baka Pygmies and 172 Bantus in the north of Gabon (Woleu Ntem Province). Plasmodium infections were characterized by sequencing a portion of the parasite cytochrome b gene. Population genetic structure of P. falciparum in the different villages was analysed using microsatellite markers and genes coding for antigenic proteins (MSP1, MSP2, GLURP, and EBA-175). Overall, prevalence of P. falciparum was around 57 % and no significant difference of prevalence was observed between Pygmies and Bantus. No significant differences of population genetic structure of P. falciparum was found between Pygmy and Bantu people except for one antigen-coding gene, glurp, for which genetic data suggested the existence of a potentially disruptive selection acting on this gene in the two types of populations. The genetic structure of P. falciparum followed a pattern of isolation by distance at the scale of the study. The prevalence and genetic diversity of P. falciparum observed in Baka demonstrates a significant transmission of the parasite in this population, and some exchanges of parasites with Bantu neighbours. Despite that, some antigen-coding genes seem to have had a particular evolutionary trajectory in certain Pygmy populations due to specific local human and/or mosquito characteristics.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 3%
Unknown 35 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 22%
Student > Ph. D. Student 7 19%
Student > Master 4 11%
Other 3 8%
Student > Bachelor 3 8%
Other 4 11%
Unknown 7 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 25%
Biochemistry, Genetics and Molecular Biology 7 19%
Medicine and Dentistry 7 19%
Nursing and Health Professions 1 3%
Computer Science 1 3%
Other 3 8%
Unknown 8 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2015.
All research outputs
#20,293,238
of 22,829,683 outputs
Outputs from Malaria Journal
#5,329
of 5,569 outputs
Outputs of similar age
#233,836
of 278,742 outputs
Outputs of similar age from Malaria Journal
#137
of 139 outputs
Altmetric has tracked 22,829,683 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,569 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,742 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 139 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.