| Title |
Nitrated meat products are associated with mania in humans and altered behavior and brain gene expression in rats
|
|---|---|
| Published in |
Molecular Psychiatry, July 2018
|
| DOI | 10.1038/s41380-018-0105-6 |
| Pubmed ID | |
| Authors |
Seva G. Khambadkone, Zachary A. Cordner, Faith Dickerson, Emily G. Severance, Emese Prandovszky, Mikhail Pletnikov, Jianchun Xiao, Ye Li, Gretha J. Boersma, C. Conover Talbot, Wayne W. Campbell, Christian S. Wright, C. Evan Siple, Timothy H. Moran, Kellie L. Tamashiro, Robert H. Yolken |
| Abstract |
Mania is a serious neuropsychiatric condition associated with significant morbidity and mortality. Previous studies have suggested that environmental exposures can contribute to mania pathogenesis. We measured dietary exposures in a cohort of individuals with mania and other psychiatric disorders as well as in control individuals without a psychiatric disorder. We found that a history of eating nitrated dry cured meat but not other meat or fish products was strongly and independently associated with current mania (adjusted odds ratio 3.49, 95% confidence interval (CI) 2.24-5.45, p < 8.97 × 10-8). Lower odds of association were found between eating nitrated dry cured meat and other psychiatric disorders. We further found that the feeding of meat preparations with added nitrate to rats resulted in hyperactivity reminiscent of human mania, alterations in brain pathways that have been implicated in human bipolar disorder, and changes in intestinal microbiota. These findings may lead to new methods for preventing mania and for developing novel therapeutic interventions. |
X Demographics
The data shown below were collected from the profiles of 211 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 28 | 13% |
| Spain | 20 | 9% |
| United Kingdom | 5 | 2% |
| France | 4 | 2% |
| Turkey | 3 | 1% |
| Canada | 3 | 1% |
| Italy | 3 | 1% |
| Venezuela, Bolivarian Republic of | 3 | 1% |
| Chile | 3 | 1% |
| Other | 22 | 10% |
| Unknown | 117 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 170 | 81% |
| Scientists | 20 | 9% |
| Practitioners (doctors, other healthcare professionals) | 19 | 9% |
| Science communicators (journalists, bloggers, editors) | 2 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 106 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 11% |
| Student > Bachelor | 11 | 10% |
| Researcher | 9 | 8% |
| Other | 8 | 8% |
| Student > Master | 7 | 7% |
| Other | 17 | 16% |
| Unknown | 42 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 13% |
| Agricultural and Biological Sciences | 11 | 10% |
| Biochemistry, Genetics and Molecular Biology | 7 | 7% |
| Neuroscience | 7 | 7% |
| Nursing and Health Professions | 4 | 4% |
| Other | 16 | 15% |
| Unknown | 47 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1003. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2023.
All research outputs
#16,322
of 25,708,267 outputs
Outputs from Molecular Psychiatry
#14
of 4,656 outputs
Outputs of similar age
#311
of 341,463 outputs
Outputs of similar age from Molecular Psychiatry
#1
of 95 outputs
Altmetric has tracked 25,708,267 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,656 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,463 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.