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Likelihood of infection in patients with presumed sepsis at the time of intensive care unit admission: a cohort study

Overview of attention for article published in Critical Care, December 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

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2 news outlets
blogs
1 blog
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30 X users
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1 Facebook page

Citations

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192 Dimensions

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183 Mendeley
Title
Likelihood of infection in patients with presumed sepsis at the time of intensive care unit admission: a cohort study
Published in
Critical Care, December 2015
DOI 10.1186/s13054-015-1035-1
Pubmed ID
Authors

Peter M. C. Klein Klouwenberg, Olaf L. Cremer, Lonneke A. van Vught, David S. Y. Ong, Jos F. Frencken, Marcus J. Schultz, Marc J. Bonten, Tom van der Poll

Abstract

A clinical suspicion of infection is mandatory for diagnosing sepsis in patients with a systemic inflammatory response syndrome. Yet, the accuracy of categorizing critically ill patients presenting to the intensive care unit (ICU) as being infected or not is unknown. We therefore assessed the likelihood of infection in patients who were treated for sepsis upon admission to the ICU, and quantified the association between plausibility of infection and mortality. We studied a cohort of critically ill patients admitted with clinically suspected sepsis to two tertiary ICUs in the Netherlands between January 2011 and December 2013. The likelihood of infection was categorized as none, possible, probable or definite by post-hoc assessment. We used multivariable competing risks survival analyses to determine the association of the plausibility of infection with mortality. Among 2579 patients treated for sepsis, 13% had a post-hoc infection likelihood of "none", and an additional 30% of only "possible". These percentages were largely similar for different suspected sites of infection. In crude analyses, the likelihood of infection was associated with increased length of stay and complications. In multivariable analysis, patients with an unlikely infection had a higher mortality rate compared to patients with a definite infection (subdistribution hazard ratio 1.23; 95% confidence interval 1.03-1.49). This study is the first prospective analysis to show that the clinical diagnosis of sepsis upon ICU admission corresponds poorly with the presence of infection on post-hoc assessment. A higher likelihood of infection does not adversely influence outcome in this population. ClinicalTrials.gov NCT01905033 . Registered 11 July 2013.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 183 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Unknown 182 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 28 15%
Student > Ph. D. Student 23 13%
Student > Bachelor 23 13%
Other 20 11%
Student > Master 12 7%
Other 31 17%
Unknown 46 25%
Readers by discipline Count As %
Medicine and Dentistry 96 52%
Biochemistry, Genetics and Molecular Biology 7 4%
Agricultural and Biological Sciences 6 3%
Nursing and Health Professions 5 3%
Engineering 3 2%
Other 14 8%
Unknown 52 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 42. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2020.
All research outputs
#988,252
of 25,373,627 outputs
Outputs from Critical Care
#770
of 6,554 outputs
Outputs of similar age
#16,478
of 395,397 outputs
Outputs of similar age from Critical Care
#47
of 466 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,397 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 466 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.