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Cancer cell–selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules

Overview of attention for article published in Nature Medicine, November 2011
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Citations

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845 Dimensions

Readers on

mendeley
657 Mendeley
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1 CiteULike
Title
Cancer cell–selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules
Published in
Nature Medicine, November 2011
DOI 10.1038/nm.2554
Pubmed ID
Authors

Makoto Mitsunaga, Mikako Ogawa, Nobuyuki Kosaka, Lauren T Rosenblum, Peter L Choyke, Hisataka Kobayashi

Abstract

Three major modes of cancer therapy (surgery, radiation and chemotherapy) are the mainstay of modern oncologic therapy. To minimize the side effects of these therapies, molecular-targeted cancer therapies, including armed antibody therapy, have been developed with limited success. In this study, we have developed a new type of molecular-targeted cancer therapy, photoimmunotherapy (PIT), that uses a target-specific photosensitizer based on a near-infrared (NIR) phthalocyanine dye, IR700, conjugated to monoclonal antibodies (mAbs) targeting epidermal growth factor receptors. Cell death was induced immediately after irradiating mAb-IR700-bound target cells with NIR light. We observed in vivo tumor shrinkage after irradiation with NIR light in target cells expressing the epidermal growth factor receptor. The mAb-IR700 conjugates were most effective when bound to the cell membrane and produced no phototoxicity when not bound, suggesting a different mechanism for PIT as compared to conventional photodynamic therapies. Target-selective PIT enables treatment of cancer based on mAb binding to the cell membrane.

X Demographics

X Demographics

The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 657 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 16 2%
United States 7 1%
Germany 2 <1%
Netherlands 2 <1%
Spain 2 <1%
United Kingdom 2 <1%
Canada 1 <1%
Belgium 1 <1%
Hungary 1 <1%
Other 4 <1%
Unknown 619 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 137 21%
Researcher 123 19%
Student > Master 69 11%
Student > Bachelor 57 9%
Student > Doctoral Student 38 6%
Other 97 15%
Unknown 136 21%
Readers by discipline Count As %
Chemistry 128 19%
Agricultural and Biological Sciences 102 16%
Medicine and Dentistry 91 14%
Biochemistry, Genetics and Molecular Biology 60 9%
Engineering 42 6%
Other 82 12%
Unknown 152 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 112. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2023.
All research outputs
#377,870
of 25,525,181 outputs
Outputs from Nature Medicine
#1,330
of 9,368 outputs
Outputs of similar age
#1,366
of 154,333 outputs
Outputs of similar age from Nature Medicine
#6
of 139 outputs
Altmetric has tracked 25,525,181 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,368 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 105.3. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 154,333 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 139 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.