| Title |
Elucidating the genetic basis of social interaction and isolation
|
|---|---|
| Published in |
Nature Communications, July 2018
|
| DOI | 10.1038/s41467-018-04930-1 |
| Pubmed ID | |
| Authors |
Felix R. Day, Ken K. Ong, John R. B. Perry |
| Abstract |
The negative impacts of social isolation and loneliness on health are well documented. However, little is known about their possible biological determinants. In up to 452,302 UK Biobank study participants, we perform genome-wide association study analyses for loneliness and regular participation in social activities. We identify 15 genomic loci (P < 5 × 10-8) for loneliness, and demonstrate a likely causal association between adiposity and increased susceptibility to loneliness and depressive symptoms. Further loci were identified for regular attendance at a sports club or gym (N = 6 loci), pub or social club (N = 13) or religious group (N = 18). Across these traits there was strong enrichment for genes expressed in brain regions that control emotional expression and behaviour. We demonstrate aetiological mechanisms specific to each trait, in addition to identifying loci that are pleiotropic across multiple complex traits. Further study of these traits may identify novel modifiable risk factors associated with social withdrawal and isolation. |
X Demographics
The data shown below were collected from the profiles of 121 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 16 | 13% |
| United Kingdom | 10 | 8% |
| Chile | 8 | 7% |
| Spain | 7 | 6% |
| Japan | 6 | 5% |
| Mexico | 4 | 3% |
| Netherlands | 3 | 2% |
| Argentina | 2 | 2% |
| India | 2 | 2% |
| Other | 16 | 13% |
| Unknown | 47 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 79 | 65% |
| Scientists | 34 | 28% |
| Practitioners (doctors, other healthcare professionals) | 5 | 4% |
| Science communicators (journalists, bloggers, editors) | 3 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 220 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 220 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 40 | 18% |
| Researcher | 35 | 16% |
| Student > Bachelor | 25 | 11% |
| Student > Master | 19 | 9% |
| Student > Doctoral Student | 14 | 6% |
| Other | 36 | 16% |
| Unknown | 51 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 29 | 13% |
| Agricultural and Biological Sciences | 26 | 12% |
| Psychology | 25 | 11% |
| Neuroscience | 22 | 10% |
| Medicine and Dentistry | 20 | 9% |
| Other | 41 | 19% |
| Unknown | 57 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 406. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2023.
All research outputs
#74,557
of 25,738,558 outputs
Outputs from Nature Communications
#1,145
of 58,285 outputs
Outputs of similar age
#1,557
of 342,327 outputs
Outputs of similar age from Nature Communications
#32
of 1,256 outputs
Altmetric has tracked 25,738,558 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 58,285 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.4. This one has done particularly well, scoring higher than 98% of its peers.
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