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A novel small molecule inhibitor of Candida albicans biofilm formation, filamentation and virulence with low potential for the development of resistance

Overview of attention for article published in npj Biofilms and Microbiomes, August 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

blogs
1 blog
twitter
6 X users
facebook
5 Facebook pages

Citations

dimensions_citation
103 Dimensions

Readers on

mendeley
144 Mendeley
Title
A novel small molecule inhibitor of Candida albicans biofilm formation, filamentation and virulence with low potential for the development of resistance
Published in
npj Biofilms and Microbiomes, August 2015
DOI 10.1038/npjbiofilms.2015.12
Pubmed ID
Authors

Christopher G Pierce, Ashok K Chaturvedi, Anna L Lazzell, Alexander T Powell, Stephen P Saville, Stanton F McHardy, Jose L Lopez-Ribot

Abstract

Candida albicans is the principal causative agent of candidiasis, the most common fungal infection in humans. Candidiasis represents the third-to-fourth most frequent nosocomial infection worldwide, as this normal commensal of humans causes opportunistic infections in an expanding population of immune- and medically-compromised patients. These infections are frequently associated with biofilm formation, which complicates treatment and contributes to unacceptably high mortality rates. To address the pressing need for new antifungals we have performed a high content screen of 20,000 small molecules in a chemical library (NOVACore™) to identify compounds that inhibit C. albicans biofilm formation, and conducted a series of follow-up studies to examine the in vitro and in vivo activity of the identified compounds. The screen identified a novel series of diazaspiro-decane structural analogs which were largely represented among the bioactive compounds. Characterization of the leading compound from this series indicated that it inhibits processes associated with C. albicans virulence, most notably biofilm formation and filamentation, without having an effect on overall growth or eliciting resistance. This compound demonstrated in vivo activity in clinically-relevant murine models of both invasive and oral candidiasis and as such represents a promising lead for antifungal drug development. Furthermore, these results provide proof of concept for the implementation of anti-virulence approaches against C. albicans and other fungal infections that would be less likely to foster the emergence of resistance.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 144 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 143 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 32 22%
Researcher 20 14%
Student > Ph. D. Student 19 13%
Student > Bachelor 15 10%
Student > Postgraduate 9 6%
Other 26 18%
Unknown 23 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 21%
Biochemistry, Genetics and Molecular Biology 28 19%
Immunology and Microbiology 21 15%
Medicine and Dentistry 13 9%
Pharmacology, Toxicology and Pharmaceutical Science 5 3%
Other 18 13%
Unknown 29 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2020.
All research outputs
#2,766,304
of 22,821,814 outputs
Outputs from npj Biofilms and Microbiomes
#193
of 395 outputs
Outputs of similar age
#37,198
of 264,494 outputs
Outputs of similar age from npj Biofilms and Microbiomes
#2
of 5 outputs
Altmetric has tracked 22,821,814 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 395 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.3. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,494 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.