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Insights into the skin microbiome dynamics of leprosy patients during multi-drug therapy and in healthy individuals from Brazil

Overview of attention for article published in Scientific Reports, June 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

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1 blog
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10 X users
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1 patent

Citations

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66 Mendeley
Title
Insights into the skin microbiome dynamics of leprosy patients during multi-drug therapy and in healthy individuals from Brazil
Published in
Scientific Reports, June 2018
DOI 10.1038/s41598-018-27074-0
Pubmed ID
Authors

Paulo E. S. Silva, Mariana P. Reis, Marcelo P. Ávila, Marcela F. Dias, Patrícia S. Costa, Maria L. S. Suhadolnik, Bárbara G. Kunzmann, Anderson O. Carmo, Evanguedes Kalapotakis, Edmar Chartone-Souza, Andréa M. A. Nascimento

Abstract

Leprosy is a chronic infectious peripheral neuropathy that is caused by Mycobacterium leprae, and the skin is one of its preferred target sites. However, the effects of this infection on the skin microbiome remain largely unexplored. Here, we characterize and compare the lesional and non-lesional skin microbiomes of leprosy patients and healthy individuals through the deep sequencing of 16 S rRNA genes. Additionally, a subset of patients was monitored throughout the multi-drug therapy to investigate its effect on the leprous skin microbiome. Firmicutes-associated OTUs (primarily Staphylococcus) prevailed in healthy individuals. By contrast, Firmicutes was underrepresented and Proteobacteria was enriched in the patients' skin, although a single dominant taxon has not been observed at a finer taxonomic resolution. These differences can be explained by the significant decrease in Staphylococcus and Streptococcus as well as the enrichment in Brevundimonas. The overrepresentation of Micrococcus in patients is also remarkable. Genus-level compositional profiles revealed no significant intrapersonal difference between lesional and non-lesional sites. Treatment-associated changes indicated a loss of diversity and a shift in the community composition, with stronger impacts on the OTUs that are considered indigenous bacteria. Therefore, the molecular signatures associated with leprosy identified herein might be of importance for early diagnostics.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 66 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 17%
Student > Bachelor 7 11%
Student > Doctoral Student 6 9%
Lecturer 5 8%
Student > Master 5 8%
Other 12 18%
Unknown 20 30%
Readers by discipline Count As %
Medicine and Dentistry 12 18%
Agricultural and Biological Sciences 9 14%
Biochemistry, Genetics and Molecular Biology 7 11%
Nursing and Health Professions 4 6%
Immunology and Microbiology 3 5%
Other 8 12%
Unknown 23 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2022.
All research outputs
#2,372,873
of 24,885,505 outputs
Outputs from Scientific Reports
#20,988
of 136,320 outputs
Outputs of similar age
#48,005
of 335,048 outputs
Outputs of similar age from Scientific Reports
#579
of 3,579 outputs
Altmetric has tracked 24,885,505 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 136,320 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.7. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,048 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 3,579 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.