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Insights into the skin microbiome dynamics of leprosy patients during multi-drug therapy and in healthy individuals from Brazil

Overview of attention for article published in Scientific Reports, June 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

blogs
1 blog
twitter
10 tweeters

Citations

dimensions_citation
9 Dimensions

Readers on

mendeley
46 Mendeley
Title
Insights into the skin microbiome dynamics of leprosy patients during multi-drug therapy and in healthy individuals from Brazil
Published in
Scientific Reports, June 2018
DOI 10.1038/s41598-018-27074-0
Pubmed ID
Authors

Paulo E. S. Silva, Mariana P. Reis, Marcelo P. Ávila, Marcela F. Dias, Patrícia S. Costa, Maria L. S. Suhadolnik, Bárbara G. Kunzmann, Anderson O. Carmo, Evanguedes Kalapotakis, Edmar Chartone-Souza, Andréa M. A. Nascimento

Abstract

Leprosy is a chronic infectious peripheral neuropathy that is caused by Mycobacterium leprae, and the skin is one of its preferred target sites. However, the effects of this infection on the skin microbiome remain largely unexplored. Here, we characterize and compare the lesional and non-lesional skin microbiomes of leprosy patients and healthy individuals through the deep sequencing of 16 S rRNA genes. Additionally, a subset of patients was monitored throughout the multi-drug therapy to investigate its effect on the leprous skin microbiome. Firmicutes-associated OTUs (primarily Staphylococcus) prevailed in healthy individuals. By contrast, Firmicutes was underrepresented and Proteobacteria was enriched in the patients' skin, although a single dominant taxon has not been observed at a finer taxonomic resolution. These differences can be explained by the significant decrease in Staphylococcus and Streptococcus as well as the enrichment in Brevundimonas. The overrepresentation of Micrococcus in patients is also remarkable. Genus-level compositional profiles revealed no significant intrapersonal difference between lesional and non-lesional sites. Treatment-associated changes indicated a loss of diversity and a shift in the community composition, with stronger impacts on the OTUs that are considered indigenous bacteria. Therefore, the molecular signatures associated with leprosy identified herein might be of importance for early diagnostics.

Twitter Demographics

The data shown below were collected from the profiles of 10 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 24%
Student > Bachelor 7 15%
Student > Doctoral Student 4 9%
Student > Master 4 9%
Student > Ph. D. Student 4 9%
Other 5 11%
Unknown 11 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 20%
Medicine and Dentistry 7 15%
Biochemistry, Genetics and Molecular Biology 4 9%
Nursing and Health Professions 3 7%
Immunology and Microbiology 3 7%
Other 6 13%
Unknown 14 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2018.
All research outputs
#2,220,495
of 18,822,351 outputs
Outputs from Scientific Reports
#18,786
of 100,923 outputs
Outputs of similar age
#52,340
of 291,420 outputs
Outputs of similar age from Scientific Reports
#1
of 9 outputs
Altmetric has tracked 18,822,351 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 100,923 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.0. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,420 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them