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Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

Overview of attention for article published in Nature Genetics, December 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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1 policy source
twitter
3 X users
wikipedia
3 Wikipedia pages

Citations

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631 Dimensions

Readers on

mendeley
313 Mendeley
citeulike
3 CiteULike
Title
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
Published in
Nature Genetics, December 2008
DOI 10.1038/ng.288
Pubmed ID
Authors

Valeriya Lyssenko, Cecilia L F Nagorny, Michael R Erdos, Nils Wierup, Anna Jonsson, Peter Spégel, Marco Bugliani, Richa Saxena, Malin Fex, Nicolo Pulizzi, Bo Isomaa, Tiinamaija Tuomi, Peter Nilsson, Johanna Kuusisto, Jaakko Tuomilehto, Michael Boehnke, David Altshuler, Frank Sundler, Johan G Eriksson, Anne U Jackson, Markku Laakso, Piero Marchetti, Richard M Watanabe, Hindrik Mulder, Leif Groop

Abstract

Genome-wide association studies have shown that variation in MTNR1B (melatonin receptor 1B) is associated with insulin and glucose concentrations. Here we show that the risk genotype of this SNP predicts future type 2 diabetes (T2D) in two large prospective studies. Specifically, the risk genotype was associated with impairment of early insulin response to both oral and intravenous glucose and with faster deterioration of insulin secretion over time. We also show that the MTNR1B mRNA is expressed in human islets, and immunocytochemistry confirms that it is primarily localized in beta cells in islets. Nondiabetic individuals carrying the risk allele and individuals with T2D showed increased expression of the receptor in islets. Insulin release from clonal beta cells in response to glucose was inhibited in the presence of melatonin. These data suggest that the circulating hormone melatonin, which is predominantly released from the pineal gland in the brain, is involved in the pathogenesis of T2D. Given the increased expression of MTNR1B in individuals at risk of T2D, the pathogenic effects are likely exerted via a direct inhibitory effect on beta cells. In view of these results, blocking the melatonin ligand-receptor system could be a therapeutic avenue in T2D.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 313 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 2 <1%
United States 2 <1%
United Kingdom 2 <1%
Malaysia 1 <1%
Hong Kong 1 <1%
Costa Rica 1 <1%
Finland 1 <1%
Sweden 1 <1%
Mexico 1 <1%
Other 3 <1%
Unknown 298 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 67 21%
Researcher 66 21%
Student > Bachelor 28 9%
Student > Master 23 7%
Professor 21 7%
Other 61 19%
Unknown 47 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 91 29%
Medicine and Dentistry 64 20%
Biochemistry, Genetics and Molecular Biology 56 18%
Pharmacology, Toxicology and Pharmaceutical Science 8 3%
Psychology 6 2%
Other 33 11%
Unknown 55 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 December 2018.
All research outputs
#4,123,471
of 23,613,071 outputs
Outputs from Nature Genetics
#4,015
of 7,296 outputs
Outputs of similar age
#22,301
of 168,514 outputs
Outputs of similar age from Nature Genetics
#42
of 61 outputs
Altmetric has tracked 23,613,071 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,296 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.8. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 168,514 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.