| Title |
High genetic risk individuals benefit less from resistance exercise intervention
|
|---|---|
| Published in |
International Journal of Obesity, April 2015
|
| DOI | 10.1038/ijo.2015.78 |
| Pubmed ID | |
| Authors |
Y C Klimentidis, J W Bea, T Lohman, P-S Hsieh, S Going, Z Chen |
| Abstract |
Background/ObjectivesGenetic factors play an important role in body mass index (BMI) variation, and also likely play a role in the weight-loss and body composition response to physical activity/exercise. With the recent identification of BMI-associated genetic variants, it is possible to investigate the interaction of these genetic factors with exercise on body composition outcomes.Subjects/MethodsIn a block-randomized clinical trial of resistance exercise among women (n=148), we examined whether the putative effect of exercise on weight and DXA-derived body composition measurements differs according to genetic risk for obesity. Approximately one-half of the sample was randomized to an intervention consisting of a supervised, intensive, resistance exercise program, lasting one year. Genetic risk for obesity was defined as a genetic risk score (GRS) comprised of 21 SNPs known to be associated with normal BMI variation. We examined the interaction of exercise intervention and the GRS on anthropometric and body composition measurements after one year of the exercise intervention.ResultsWe found statistically significant interactions for body weight (P=0.01), body fat (P=0.01), body fat % (P=0.02), and abdominal fat (P=0.02), whereby the putative effect of exercise is greater among those with a lower level of genetic risk for obesity. No single SNP appears to be a major driver of these interactions.ConclusionsThe weight-loss response to resistance exercise, including changes in body composition, differs according to an individual's genetic risk for obesity.International Journal of Obesity accepted article preview online, 30 April 2015. doi:10.1038/ijo.2015.78. |
X Demographics
The data shown below were collected from the profiles of 55 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 11 | 20% |
| Canada | 9 | 16% |
| Spain | 4 | 7% |
| United Kingdom | 3 | 5% |
| Japan | 2 | 4% |
| Mexico | 1 | 2% |
| Cabo Verde | 1 | 2% |
| New Zealand | 1 | 2% |
| Russia | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 20 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 31 | 56% |
| Practitioners (doctors, other healthcare professionals) | 13 | 24% |
| Scientists | 9 | 16% |
| Science communicators (journalists, bloggers, editors) | 2 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 136 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 12% |
| Researcher | 12 | 9% |
| Student > Master | 12 | 9% |
| Student > Doctoral Student | 9 | 7% |
| Lecturer | 8 | 6% |
| Other | 32 | 24% |
| Unknown | 47 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 22 | 16% |
| Sports and Recreations | 16 | 12% |
| Medicine and Dentistry | 12 | 9% |
| Agricultural and Biological Sciences | 11 | 8% |
| Biochemistry, Genetics and Molecular Biology | 8 | 6% |
| Other | 10 | 7% |
| Unknown | 57 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 66. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2020.
All research outputs
#639,838
of 25,196,456 outputs
Outputs from International Journal of Obesity
#351
of 4,517 outputs
Outputs of similar age
#7,420
of 269,786 outputs
Outputs of similar age from International Journal of Obesity
#10
of 86 outputs
Altmetric has tracked 25,196,456 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,517 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.3. This one has done particularly well, scoring higher than 92% of its peers.
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We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.