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Effect of diuretics and sodium-restricted diet on sleep apnea severity: study protocol for a randomized controlled trial

Overview of attention for article published in Trials, April 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
2 tweeters
peer_reviews
1 peer review site

Citations

dimensions_citation
7 Dimensions

Readers on

mendeley
59 Mendeley
Title
Effect of diuretics and sodium-restricted diet on sleep apnea severity: study protocol for a randomized controlled trial
Published in
Trials, April 2015
DOI 10.1186/s13063-015-0699-9
Pubmed ID
Authors

Cintia Zappe Fiori, Denis Martinez, Sandro Cadaval Gonçalves, Carolina Caruccio Montanari, Flavio Danni Fuchs

Abstract

Obstructive sleep apnea occurs as a result of increased collapsibility of the upper airway. Overnight fluid displacement from the legs to the neck causes pharyngeal narrowing and increased apnea severity. Sodium intake is associated with apnea severity. We hypothesized that interventions that decrease bodily fluid content might reduce the severity of sleep apnea. This is a randomized clinical trial including men with an apnea-hypopnea index greater than 30 events/hour, previously diagnosed by full-night in-laboratory polysomnography. A total of 54 men will be included and randomly assigned to three groups: Diuretic (n = 18), sodium-restricted diet (n = 18), and control (n = 18). The intervention will last one week. Intention-to-treat and per-protocol analyses will be performed. The diuretic group will receive combined spironolactone 100 mg plus furosemide 20 mg daily, taken in the morning. The diet group will receive a regimen with a maximum intake of 3 g of sodium per day. The control group will receive a placebo pill and will maintain all eating habits while keeping a recall diary of their dietary behavior. The primary outcome measure will be change in apnea-hypopnea index. The secondary outcome measures will be variations of: anthropometric and bioelectrical impedance variables, office blood pressure, respiratory variables from in-home level III polysomnography, excessive daytime sleepiness, glycolipid profile, C-reactive protein, 24 h urinary variables, and adverse events. Despite the high efficacy of continuous positive airway pressure to reverse upper airway obstruction in sleep apnea, partial adherence to this form of treatment reduces its efficiency. Thus, additional forms of treating apnea need to be investigated. If the results of this proof-of-concept trial show that decreases in bodily fluid content, either by diuretic or dietary intervention, reduces the severity of sleep apnea, further investigation will be necessary before these results can be translated and adopted as an adjunct apnea therapy. clinicaltrials.gov NCT01945801.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 59 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 19%
Student > Bachelor 8 14%
Researcher 5 8%
Student > Ph. D. Student 4 7%
Unspecified 4 7%
Other 13 22%
Unknown 14 24%
Readers by discipline Count As %
Medicine and Dentistry 24 41%
Nursing and Health Professions 8 14%
Unspecified 4 7%
Psychology 3 5%
Computer Science 1 2%
Other 5 8%
Unknown 14 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2015.
All research outputs
#5,765,107
of 11,106,930 outputs
Outputs from Trials
#1,374
of 2,663 outputs
Outputs of similar age
#84,919
of 213,760 outputs
Outputs of similar age from Trials
#59
of 125 outputs
Altmetric has tracked 11,106,930 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,663 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 213,760 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 125 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.