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Mindfulness-based exposure and response prevention for obsessive compulsive disorder: study protocol for a pilot randomised controlled trial

Overview of attention for article published in Trials, April 2015
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Title
Mindfulness-based exposure and response prevention for obsessive compulsive disorder: study protocol for a pilot randomised controlled trial
Published in
Trials, April 2015
DOI 10.1186/s13063-015-0664-7
Pubmed ID
Authors

Clara Strauss, Claire Rosten, Mark Hayward, Laura Lea, Elizabeth Forrester, Anna-Marie Jones

Abstract

Obsessive Compulsive Disorder (OCD) is a distressing and debilitating condition affecting 1-2% of the population. Exposure and response prevention (ERP) is a behaviour therapy for OCD with the strongest evidence for effectiveness of any psychological therapy for the condition. Even so, only about half of people offered ERP show recovery after the therapy. An important reason for ERP failure is that about 25% of people drop out early, and even for those who continue with the therapy, many do not regularly engage in ERP tasks, an essential element of ERP. A mindfulness-based approach has the potential to reduce drop-out from ERP and to improve ERP task engagement with an emphasis on accepting difficult thoughts, feelings and bodily sessions and on becoming more aware of urges, rather than automatically acting on them. This is a pilot randomised controlled trial of mindfulness-based ERP (MB-ERP) with the aim of establishing parameters for a definitive trial. Forty participants diagnosed with OCD will be allocated at random to a 10-session ERP group or to a 10-session MB-ERP group. Primary outcomes are OCD symptom severity and therapy engagement. Secondary outcomes are depressive symptom severity, wellbeing and obsessive-compulsive beliefs. A semi-structured interview with participants will guide understanding of change processes. Findings from this pilot study will inform future research in this area, and if effect sizes on primary outcomes are in favour of MB-ERP in comparison to ERP, funding for a definitive trial will be sought. Current Controlled Trials registration number ISRCTN52684820 . Registered on 30 January 2014.

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Geographical breakdown

Country Count As %
Brazil 1 <1%
Unknown 204 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 13%
Student > Master 25 12%
Researcher 24 12%
Student > Doctoral Student 23 11%
Student > Bachelor 17 8%
Other 46 22%
Unknown 43 21%
Readers by discipline Count As %
Psychology 84 41%
Medicine and Dentistry 26 13%
Nursing and Health Professions 12 6%
Social Sciences 10 5%
Neuroscience 4 2%
Other 16 8%
Unknown 53 26%