| Title |
Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptors
|
|---|---|
| Published in |
Nature Medicine, October 2011
|
| DOI | 10.1038/nm.2435 |
| Pubmed ID | |
| Authors |
Fabrizio Benedetti, Martina Amanzio, Rosalba Rosato, Catherine Blanchard |
| Abstract |
Placebo analgesia is mediated by both opioid and nonopioid mechanisms, but so far nothing is known about the nonopioid component. Here we show that the specific CB1 cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide (rimonabant or SR141716) blocks nonopioid placebo analgesic responses but has no effect on opioid placebo responses. These findings suggest that the endocannabinoid system has a pivotal role in placebo analgesia in some circumstances when the opioid system is not involved. |
X Demographics
The data shown below were collected from the profiles of 112 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 22 | 20% |
| United Kingdom | 5 | 4% |
| Denmark | 3 | 3% |
| Canada | 3 | 3% |
| Australia | 3 | 3% |
| Switzerland | 2 | 2% |
| France | 2 | 2% |
| Japan | 2 | 2% |
| Spain | 2 | 2% |
| Other | 10 | 9% |
| Unknown | 58 | 52% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 95 | 85% |
| Scientists | 12 | 11% |
| Practitioners (doctors, other healthcare professionals) | 4 | 4% |
| Unknown | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 273 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 2% |
| Germany | 4 | 1% |
| Italy | 2 | <1% |
| Switzerland | 1 | <1% |
| Austria | 1 | <1% |
| Portugal | 1 | <1% |
| United Kingdom | 1 | <1% |
| Brazil | 1 | <1% |
| Denmark | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 255 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 51 | 19% |
| Student > Bachelor | 40 | 15% |
| Student > Master | 38 | 14% |
| Student > Ph. D. Student | 20 | 7% |
| Professor | 17 | 6% |
| Other | 64 | 23% |
| Unknown | 43 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 70 | 26% |
| Psychology | 39 | 14% |
| Neuroscience | 35 | 13% |
| Agricultural and Biological Sciences | 31 | 11% |
| Nursing and Health Professions | 7 | 3% |
| Other | 37 | 14% |
| Unknown | 54 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 142. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2023.
All research outputs
#296,032
of 25,670,640 outputs
Outputs from Nature Medicine
#1,100
of 9,396 outputs
Outputs of similar age
#1,057
of 144,995 outputs
Outputs of similar age from Nature Medicine
#2
of 134 outputs
Altmetric has tracked 25,670,640 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,396 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 105.5. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 144,995 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 134 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.