| Title |
Cas Adaptor Proteins Coordinate Sensory Axon Fasciculation
|
|---|---|
| Published in |
Scientific Reports, April 2018
|
| DOI | 10.1038/s41598-018-24261-x |
| Pubmed ID | |
| Authors |
Tyler A. Vahedi-Hunter, Jason A. Estep, Kylee A. Rosette, Michael L. Rutlin, Kevin M. Wright, Martin M. Riccomagno |
| Abstract |
Development of complex neural circuits like the peripheral somatosensory system requires intricate mechanisms to ensure axons make proper connections. While much is known about ligand-receptor pairs required for dorsal root ganglion (DRG) axon guidance, very little is known about the cytoplasmic effectors that mediate cellular responses triggered by these guidance cues. Here we show that members of the Cas family of cytoplasmic signaling adaptors are highly phosphorylated in central projections of the DRG as they enter the spinal cord. Furthermore, we provide genetic evidence that Cas proteins regulate fasciculation of DRG sensory projections. These data establish an evolutionarily conserved requirement for Cas adaptor proteins during peripheral nervous system axon pathfinding. They also provide insight into the interplay between axonal fasciculation and adhesion to the substrate. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 36% |
| Student > Master | 4 | 18% |
| Student > Bachelor | 1 | 5% |
| Professor | 1 | 5% |
| Researcher | 1 | 5% |
| Other | 2 | 9% |
| Unknown | 5 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 6 | 27% |
| Biochemistry, Genetics and Molecular Biology | 5 | 23% |
| Agricultural and Biological Sciences | 3 | 14% |
| Psychology | 2 | 9% |
| Medicine and Dentistry | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 4 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2019.
All research outputs
#18,603,172
of 23,043,346 outputs
Outputs from Scientific Reports
#94,256
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#231,149
of 296,868 outputs
Outputs of similar age from Scientific Reports
#2,567
of 3,430 outputs
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