Title |
Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels
|
---|---|
Published in |
Nature, September 1989
|
DOI | 10.1038/341233a0 |
Pubmed ID | |
Authors |
Patrik Rorsman, Per-Olof Berggren, Krister Bokvist, Hans Ericson, Hanns Möhler, Claes-Göran Östenson, Paul A. Smith |
Abstract |
The endocrine part of the pancreas plays a central role in blood-glucose regulation. It is well established that an elevation of glucose concentration reduces secretion of the hyperglycaemia-associated hormone glucagon from pancreatic alpha 2 cells. The mechanisms involved, however, remain unknown. Electrophysiological studies have demonstrated that alpha 2 cells generate Ca2+-dependent action potentials. The frequency of these action potentials, which increases under conditions that stimulate glucagon release, is not affected by glucose or insulin. The inhibitory neurotransmitter gamma-aminobutyric acid (GABA) is present in the endocrine part of the pancreas at concentrations comparable to those encountered in the central nervous system, and co-localizes with insulin in pancreatic beta cells. We now describe a mechanism whereby GABA, co-secreted with insulin from beta cells, may mediate part of the inhibitory action of glucose on glucagon secretion by activating GABAA-receptor Cl- channels in alpha 2 cells. These observations provide a model for feedback regulation of glucagon release, which may be of significance for the understanding of the hypersecretion of glucagon frequently associated with diabetes. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | <1% |
Argentina | 1 | <1% |
Unknown | 111 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 22 | 19% |
Student > Master | 15 | 13% |
Researcher | 14 | 12% |
Student > Bachelor | 13 | 12% |
Professor > Associate Professor | 6 | 5% |
Other | 16 | 14% |
Unknown | 27 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 34 | 30% |
Agricultural and Biological Sciences | 18 | 16% |
Medicine and Dentistry | 13 | 12% |
Neuroscience | 6 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
Other | 9 | 8% |
Unknown | 28 | 25% |