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Desynchronization of diurnal rhythms in bipolar disorder and borderline personality disorder

Overview of attention for article published in Translational Psychiatry, April 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

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Title
Desynchronization of diurnal rhythms in bipolar disorder and borderline personality disorder
Published in
Translational Psychiatry, April 2018
DOI 10.1038/s41398-018-0125-7
Pubmed ID
Authors

Oliver Carr, Kate E. A. Saunders, Amy C. Bilderbeck, Athanasios Tsanas, Niclas Palmius, John R. Geddes, Russell Foster, Maarten De Vos, Guy M. Goodwin

Abstract

It has long been proposed that diurnal rhythms are disturbed in bipolar disorder (BD). Such changes are obvious in episodes of mania or depression. However, detailed study of patients between episodes has been rare and comparison with other psychiatric disorders rarer still. Our hypothesis was that evidence for desynchronization of diurnal rhythms would be evident in BD and that we could test the specificity of any effect by studying borderline personality disorder (BPD). Individuals with BD (n = 36), BPD (n = 22) and healthy volunteers (HC, n = 25) wore a portable heart rate and actigraphy device and used a smart-phone to record self-assessed mood scores 10 times per day for 1 week. Average diurnal patterns of heart rate (HR), activity and sleep were compared within and across groups. Desynchronization in the phase of diurnal rhythms of HR compared with activity were found in BPD (+3 h) and BD (+1 h), but not in HC. A clear diurnal pattern for positive mood was found in all subject groups. The coherence between negative and irritable mood and HR showed a four-cycle per day component in BD and BPD, which was not present in HC. The findings highlight marked de-synchronisation of measured diurnal function in both BD but particularly BPD and suggest an increased association with negative and irritable mood at ultradian frequencies. These findings enhance our understanding of the underlying physiological changes associated with BPD and BD, and suggest objective markers for monitoring and potential treatment targets. Improved mood stabilisation is a translational objective for management of both patient groups.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 117 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 16%
Researcher 13 11%
Student > Master 12 10%
Student > Bachelor 11 9%
Student > Doctoral Student 8 7%
Other 22 19%
Unknown 32 27%
Readers by discipline Count As %
Medicine and Dentistry 27 23%
Psychology 12 10%
Computer Science 8 7%
Neuroscience 8 7%
Engineering 7 6%
Other 17 15%
Unknown 38 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2018.
All research outputs
#5,160,501
of 25,260,058 outputs
Outputs from Translational Psychiatry
#1,627
of 3,631 outputs
Outputs of similar age
#91,417
of 335,366 outputs
Outputs of similar age from Translational Psychiatry
#30
of 65 outputs
Altmetric has tracked 25,260,058 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,631 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.3. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,366 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.