↓ Skip to main content

The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge

Overview of attention for article published in Oncogene, October 2006
Altmetric Badge

Mentioned by

wikipedia
1 Wikipedia page

Citations

dimensions_citation
156 Dimensions

Readers on

mendeley
139 Mendeley
Title
The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge
Published in
Oncogene, October 2006
DOI 10.1038/sj.onc.1210016
Pubmed ID
Authors

L E Dow, J S Kauffman, J Caddy, A S Peterson, S M Jane, S M Russell, P O Humbert

Abstract

Altered expression of human Scribble is associated with invasive epithelial cancers, however, its role in tumour development remains unclear. Mutations in Drosophila Scribble result in loss of polarity, overproliferation and 3D-tumourous overgrowth of epithelial cells. Using complementation studies in Drosophila we recently demonstrated that expression of human Scribble can also regulate polarity and restrict tissue overgrowth. Here, we have undertaken a detailed study of human Scribble function in the polarized mammary cell line, MCF10A. We show that although Scribble does not seem to be required for apical-basal polarity or proliferation control in MCF10A cells, Scribble is essential for the control of polarity associated with directed epithelial cell migration. Scribble-depleted MCF10A cells show defective in vitro wound closure and chemotactic movement. The cells at the wound edge fail to polarize, show reduced lamellipodia formation and impaired recruitment of Cdc42 and Rac1 to the leading edge. Furthermore, we show that this function is relevant in vivo as Scribble mutant mice show defective epidermal wound healing. This data identifies an essential role for mammalian Scribble in the regulation of the polarity specifically involved in directed epithelial migration.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 139 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Japan 2 1%
Germany 1 <1%
Switzerland 1 <1%
Unknown 132 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 35 25%
Researcher 26 19%
Professor > Associate Professor 18 13%
Student > Bachelor 14 10%
Student > Master 11 8%
Other 15 11%
Unknown 20 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 66 47%
Biochemistry, Genetics and Molecular Biology 26 19%
Medicine and Dentistry 7 5%
Engineering 7 5%
Neuroscience 5 4%
Other 6 4%
Unknown 22 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2013.
All research outputs
#7,454,066
of 22,788,370 outputs
Outputs from Oncogene
#4,347
of 10,643 outputs
Outputs of similar age
#23,227
of 66,535 outputs
Outputs of similar age from Oncogene
#57
of 125 outputs
Altmetric has tracked 22,788,370 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,643 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 66,535 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 125 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.