| Title |
Disruption of imprinting caused by deletion of the H19 gene region in mice
|
|---|---|
| Published in |
Nature, May 1995
|
| DOI | 10.1038/375034a0 |
| Pubmed ID | |
| Authors |
Philip A. Leighton, Robert S. Ingram, Jonathan Eggenschwiler, Argiris Efstratiadis, Shirley M. Tilghman |
| Abstract |
The imprinted H19 gene, which encodes an untranslated RNA, lies at the end of a cluster of imprinted genes in the mouse. Imprinting of the insulin-2 and insulin-like growth factor 2 genes, which lie about 100 kilobases upstream of H19, can be disrupted by maternal inheritance of a targeted deletion of the H19 gene and its flanking sequence. Animals inheriting the H19 mutation from their mothers are 27% heavier than those inheriting it from their fathers. Paternal inheritance of the disruption has no effect, which presumably reflects the normally silent state of the paternal gene. The somatic overgrowth of heterozygotes for the maternal deletion is attributed to a gain of function of insulin-like growth factor 2, rather than a loss of function of H19. |
Mendeley readers
The data shown below were compiled from readership statistics for 154 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 3% |
| Germany | 1 | <1% |
| Netherlands | 1 | <1% |
| United Kingdom | 1 | <1% |
| Brazil | 1 | <1% |
| Japan | 1 | <1% |
| China | 1 | <1% |
| Unknown | 143 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 23% |
| Researcher | 34 | 22% |
| Student > Bachelor | 17 | 11% |
| Student > Master | 13 | 8% |
| Professor > Associate Professor | 11 | 7% |
| Other | 25 | 16% |
| Unknown | 19 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 69 | 45% |
| Biochemistry, Genetics and Molecular Biology | 45 | 29% |
| Medicine and Dentistry | 11 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 1% |
| Mathematics | 1 | <1% |
| Other | 4 | 3% |
| Unknown | 22 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2021.
All research outputs
#1,215,181
of 26,017,215 outputs
Outputs from Nature
#34,988
of 99,074 outputs
Outputs of similar age
#283
of 23,946 outputs
Outputs of similar age from Nature
#11
of 201 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 99,074 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.3. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 23,946 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 201 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.