↓ Skip to main content

Integrative structure and functional anatomy of a nuclear pore complex

Overview of attention for article published in Nature, March 2018
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

Mentioned by

news
12 news outlets
blogs
4 blogs
twitter
137 X users
patent
2 patents
facebook
1 Facebook page

Citations

dimensions_citation
444 Dimensions

Readers on

mendeley
504 Mendeley
Title
Integrative structure and functional anatomy of a nuclear pore complex
Published in
Nature, March 2018
DOI 10.1038/nature26003
Pubmed ID
Authors

Seung Joong Kim, Javier Fernandez-Martinez, Ilona Nudelman, Yi Shi, Wenzhu Zhang, Barak Raveh, Thurston Herricks, Brian D. Slaughter, Joanna A. Hogan, Paula Upla, Ilan E. Chemmama, Riccardo Pellarin, Ignacia Echeverria, Manjunatha Shivaraju, Azraa S. Chaudhury, Junjie Wang, Rosemary Williams, Jay R. Unruh, Charles H. Greenberg, Erica Y. Jacobs, Zhiheng Yu, M. Jason de la Cruz, Roxana Mironska, David L. Stokes, John D. Aitchison, Martin F. Jarrold, Jennifer L. Gerton, Steven J. Ludtke, Christopher W. Akey, Brian T. Chait, Andrej Sali, Michael P. Rout

Abstract

Nuclear pore complexes play central roles as gatekeepers of RNA and protein transport between the cytoplasm and nucleoplasm. However, their large size and dynamic nature have impeded a full structural and functional elucidation. Here we determined the structure of the entire 552-protein nuclear pore complex of the yeast Saccharomyces cerevisiae at sub-nanometre precision by satisfying a wide range of data relating to the molecular arrangement of its constituents. The nuclear pore complex incorporates sturdy diagonal columns and connector cables attached to these columns, imbuing the structure with strength and flexibility. These cables also tie together all other elements of the nuclear pore complex, including membrane-interacting regions, outer rings and RNA-processing platforms. Inwardly directed anchors create a high density of transport factor-docking Phe-Gly repeats in the central channel, organized into distinct functional units. This integrative structure enables us to rationalize the architecture, transport mechanism and evolutionary origins of the nuclear pore complex.

X Demographics

X Demographics

The data shown below were collected from the profiles of 137 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 504 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 504 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 131 26%
Researcher 73 14%
Student > Bachelor 56 11%
Student > Master 45 9%
Student > Doctoral Student 18 4%
Other 56 11%
Unknown 125 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 208 41%
Agricultural and Biological Sciences 74 15%
Chemistry 30 6%
Physics and Astronomy 10 2%
Computer Science 7 1%
Other 42 8%
Unknown 133 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 191. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2023.
All research outputs
#208,842
of 25,477,125 outputs
Outputs from Nature
#12,367
of 98,032 outputs
Outputs of similar age
#4,887
of 352,071 outputs
Outputs of similar age from Nature
#281
of 900 outputs
Altmetric has tracked 25,477,125 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,032 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.5. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,071 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 900 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.