Title |
CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
|
---|---|
Published in |
Nature, April 1992
|
DOI | 10.1038/356607a0 |
Pubmed ID | |
Authors |
Fiona A. Harding, James G. McArthur, Jane A. Gross, David H. Raulet, James P. Allison |
Abstract |
Occupancy of the T-cell antigen receptor is insufficient to induce T-cell activation optimally; a second co-stimulatory signal is required. Exposure of T-cell clones to complexes of antigen with major histocompatibility complex molecules in the absence of the co-stimulatory signal induces a state of clonal anergy. This requirement for two stimuli for T-cell activation could have an important role in vivo in establishing peripheral tolerance to antigens not encountered in the thymus. The receptor on T cells required for the co-stimulatory stimulus involved in the prevention of anergy has not been identified. The human T-cell antigen CD28 provides a signal that can synergize with T-cell antigen receptor stimulation in activating T cells to proliferate and secrete lymphokines. Here we report that a monoclonal antibody against the murine homologue of CD28 (ref. 7; J.A.G. et al., manuscript in preparation) can provide a co-stimulatory signal to naive CD4+ T cells and to T-cell clones. Moreover, we demonstrate that this co-stimulatory signal can block the induction of anergy in T-cell clones. |
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Student > Bachelor | 35 | 11% |
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