| Title |
Structural basis for recognition of diverse antidepressants by the human serotonin transporter
|
|---|---|
| Published in |
Nature Structural & Molecular Biology, January 2018
|
| DOI | 10.1038/s41594-018-0026-8 |
| Pubmed ID | |
| Authors |
Jonathan A. Coleman, Eric Gouaux |
| Abstract |
Selective serotonin reuptake inhibitors are clinically prescribed antidepressants that act by increasing the local concentrations of neurotransmitters at synapses and in extracellular spaces via blockade of the serotonin transporter. Here we report X-ray structures of engineered thermostable variants of the human serotonin transporter bound to the antidepressants sertraline, fluvoxamine, and paroxetine. The drugs prevent serotonin binding by occupying the central substrate-binding site and stabilizing the transporter in an outward-open conformation. These structures explain how residues within the central site orchestrate binding of chemically diverse inhibitors and mediate transporter drug selectivity. |
X Demographics
The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 28% |
| United Kingdom | 2 | 11% |
| Turkey | 1 | 6% |
| Thailand | 1 | 6% |
| Japan | 1 | 6% |
| Greece | 1 | 6% |
| Unknown | 7 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 67% |
| Scientists | 5 | 28% |
| Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 175 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 175 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 37 | 21% |
| Student > Bachelor | 37 | 21% |
| Researcher | 20 | 11% |
| Student > Master | 17 | 10% |
| Student > Postgraduate | 7 | 4% |
| Other | 14 | 8% |
| Unknown | 43 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 43 | 25% |
| Chemistry | 34 | 19% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 7% |
| Agricultural and Biological Sciences | 9 | 5% |
| Neuroscience | 8 | 5% |
| Other | 19 | 11% |
| Unknown | 50 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 63. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2020.
All research outputs
#679,436
of 25,382,440 outputs
Outputs from Nature Structural & Molecular Biology
#228
of 4,187 outputs
Outputs of similar age
#16,078
of 450,499 outputs
Outputs of similar age from Nature Structural & Molecular Biology
#7
of 38 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,187 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.5. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 450,499 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.