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Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis

Overview of attention for article published in Scientific Reports, January 2018
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
51 news outlets
twitter
23 tweeters
patent
1 patent
facebook
3 Facebook pages
reddit
1 Redditor

Citations

dimensions_citation
35 Dimensions

Readers on

mendeley
76 Mendeley
citeulike
1 CiteULike
Title
Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis
Published in
Scientific Reports, January 2018
DOI 10.1038/s41598-018-19641-2
Pubmed ID
Authors

Can Zhang, Ana Griciuc, Eloise Hudry, Yu Wan, Luisa Quinti, Joseph Ward, Angela M. Forte, Xunuo Shen, ChongZhao Ran, David R. Elmaleh, Rudolph E. Tanzi

Abstract

Amyloid-beta protein (Aβ) deposition is a pathological hallmark of Alzheimer's disease (AD). Aβ deposition triggers both pro-neuroinflammatory microglial activation and neurofibrillary tangle formation. Cromolyn sodium is an asthma therapeutic agent previously shown to reduce Aβ levels in transgenic AD mouse brains after one-week of treatment. Here, we further explored these effects as well as the mechanism of action of cromolyn, alone, and in combination with ibuprofen in APPSwedish-expressing Tg2576 mice. Mice were treated for 3 months starting at 5 months of age, when the earliest stages of β-amyloid deposition begin. Cromolyn, alone, or in combination with ibuprofen, almost completely abolished longer insoluble Aβ species, i.e. Aβ40 and Aβ42, but increased insoluble Aβ38 levels. In addition to its anti-aggregation effects on Aβ, cromolyn, alone, or plus ibuprofen, but not ibuprofen alone, increased microglial recruitment to, and phagocytosis of β-amyloid deposits in AD mice. Cromolyn also promoted Aβ42 uptake in microglial cell-based assays. Collectively, our data reveal robust effects of cromolyn, alone, or in combination with ibuprofen, in reducing aggregation-prone Aβ levels and inducing a neuroprotective microglial activation state favoring Aβ phagocytosis versus a pro-neuroinflammatory state. These findings support the use of cromolyn, alone, or with ibuprofen, as a potential AD therapeutic.

Twitter Demographics

The data shown below were collected from the profiles of 23 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 76 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 17 22%
Student > Ph. D. Student 13 17%
Student > Master 11 14%
Researcher 10 13%
Student > Doctoral Student 3 4%
Other 10 13%
Unknown 12 16%
Readers by discipline Count As %
Neuroscience 17 22%
Medicine and Dentistry 10 13%
Pharmacology, Toxicology and Pharmaceutical Science 8 11%
Chemistry 6 8%
Agricultural and Biological Sciences 6 8%
Other 16 21%
Unknown 13 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 417. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2021.
All research outputs
#38,834
of 17,891,883 outputs
Outputs from Scientific Reports
#553
of 96,712 outputs
Outputs of similar age
#1,439
of 377,039 outputs
Outputs of similar age from Scientific Reports
#1
of 15 outputs
Altmetric has tracked 17,891,883 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 96,712 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 377,039 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.