| Title |
Thrombin@Fe3O4 nanoparticles for use as a hemostatic agent in internal bleeding
|
|---|---|
| Published in |
Scientific Reports, January 2018
|
| DOI | 10.1038/s41598-017-18665-4 |
| Pubmed ID | |
| Authors |
Emiliya M. Shabanova, Andrey S. Drozdov, Anna F. Fakhardo, Ivan P. Dudanov, Marina S. Kovalchuk, Vladimir V. Vinogradov |
| Abstract |
Bleeding remains one of the main causes of premature mortality at present, with internal bleeding being the most dangerous case. In this paper, magnetic hemostatic nanoparticles are shown for the first time to assist in minimally invasive treatment of internal bleeding, implying the introduction directly into the circulatory system followed by localization in the bleeding zone due to the application of an external magnetic field. Nanoparticles were produced by entrapping human thrombin (THR) into a sol-gel derived magnetite matrix followed by grinding to sizes below 200 nm and subsequent colloidization. Prepared colloids show protrombotic activity and cause plasma coagulation in in vitro experiments. We also show here using a model blood vessel that the THR@ferria composite does not cause systematic thrombosis due to low activity, but being concentrated by an external magnetic field with simultaneous fibrinogen injection accelerates local hemostasis and stops the bleeding. For instance, a model vessel system with circulating blood at the puncture of the vessel wall and the application of a permanent magnetic field yielded a hemostasis time by a factor of 6.5 shorter than that observed for the control sample. Biocompatibility of composites was tested on HELF and HeLa cells and revealed no toxic effects. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 25% |
| Portugal | 1 | 13% |
| Russia | 1 | 13% |
| Italy | 1 | 13% |
| Unknown | 3 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 88% |
| Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 62 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 18% |
| Student > Master | 6 | 10% |
| Student > Ph. D. Student | 6 | 10% |
| Student > Bachelor | 5 | 8% |
| Student > Doctoral Student | 2 | 3% |
| Other | 6 | 10% |
| Unknown | 26 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 10% |
| Chemical Engineering | 4 | 6% |
| Biochemistry, Genetics and Molecular Biology | 3 | 5% |
| Chemistry | 3 | 5% |
| Other | 12 | 19% |
| Unknown | 27 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 58. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2022.
All research outputs
#751,783
of 25,721,020 outputs
Outputs from Scientific Reports
#8,135
of 142,619 outputs
Outputs of similar age
#17,190
of 453,443 outputs
Outputs of similar age from Scientific Reports
#250
of 4,102 outputs
Altmetric has tracked 25,721,020 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 142,619 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.8. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 453,443 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 4,102 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.